Protein Alignment MARK3 and Tssk

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Alignment Length: 296
• Identity: 95/296 - (32%)
• Similarity: 153/296 - (51%)
• Gaps: 21/296 - (7%)

Human    33 SRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILT---GREVAIKIIDKTQLNP 94
            |.:|.|...:.:|..|.....| |.:...||:|::|.|..|.:...   |..:|.|||||.:...
  Fly     6 SSAGIRQLGTRSSDVDALAQRG-YNVGHKIGEGSYATVITAGYADDHGHGVHLACKIIDKAKAPT 69

Human    95 TSLQKLF-REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSK 158
            ..:.|.| ||:.|:..::|.||:::..:::....:::.|.||..|::..::...|.:.||:::..
  Fly    70 DFVNKFFPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIW 134

Human   159 FRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS--------NEFTVGGKLDTFCGS 215
            |.|:..|::|.|...|.|||||.||:||...:|||:|||||:        .|.    |.:|:|||
  Fly   135 FFQMSKALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREM----KSETYCGS 195

Human   216 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL----RERVLRGKYRIPFYM 276
            ..|||||:..|:.||....|.|||||||:.:::..:|||..||.:|    |.|....:.::...:
  Fly   196 AAYAAPEVVCGRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETI 260

Human   277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHE 312
            |...:..:...|......|..|.:|:...|:....|
  Fly   261 SAQAKATVSVLLEPEAHARWNLREILNCAWLRTVEE 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		1/2 (50%)
		STKc_MARK	55..307	CDD:270974	87/267 (33%)
		UBA_MARK3_4	325..367	CDD:270590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655
		MARK1-3_C	654..751	CDD:213381
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	88/268 (33%)