Protein Alignment MARK3 and sff

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Alignment Length: 822
• Identity: 246/822 - (29%)
• Similarity: 374/822 - (45%)
• Gaps: 198/822 - (24%)

Human    47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 111
            |:....:|.|||.||:|||....|||..|.:.|::||||||::.:|:.:.|.|:.||:.|||:::
  Fly     9 AENCQFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLID 73

Human   112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVH 176
            ||:::.|.:|.|.:|.||||:|:.||||:|||||..||:..||||..||||:||:.:||...|.|
  Fly    74 HPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 138

Human   177 RDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGV 241
            ||||.||||||...||||||||.::....|..|:|.||||.||.||:.:|:||||.:.||||.||
  Fly   139 RDLKPENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGV 203

Human   242 ILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW 306
            |||.|:.|:||||..||::|.|:|.||.:.||.::..||::||:..:.:||.:|.||.:|.:..|
  Fly   204 ILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPW 268

Human   307 INAGHE-EDELK-PFVE-------PELDISDQKRIDIMVGMGYSQEE---IQESLSKMKYDEITA 359
            :.||.: |.||: |.:|       |.....|...::.:..:|..:|:   |||.||.....|...
  Fly   269 VTAGGKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVI 333

Human   360 TYLLLGRK----------------SSELDASDSSSSSNLSLAKVR----PS-SDLNNSTGQSPHH 403
            .:|||.||                .|||||.| .....|...::.    || ..::..:..:|..
  Fly   334 YFLLLERKRRRPALEDDDEIAQKSRSELDAVD-PPRKRLDTCRINGTNAPSYGQISEGSPLTPRR 397

Human   404 KV--QRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIA 466
            :.  .||.||::..:|.|       |:.|....||.:..:.:..... :||.:...:|:.    .
  Fly   398 QAFNFRSYSSTRNHQRRS-------PTTVTSSVRSSSYHSPTRCNSP-MSSAQQQANAIS----R 450

Human   467 PASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTI 531
            |:||..|                             ||.:||  .:|..:..||.:
  Fly   451 PSSPAAG-----------------------------TRHSTY--GDRDRSGHHSSV--------- 475

Human   532 PDQRTPVASTHSISSAATPD--RIRFP----RGTASRSTFHGQPRERRTATYNGPP--------- 581
              .|||   :||...:...|  .:|.|    |.:..:....|.||:|.....  ||
  Fly   476 --SRTP---SHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGI--PPGSPGGNSSG 533

Human   582 ---ASPSLSHEA------------------------TPLSQTRSRG------STNLFSKLTSKLT 613
               ||||:.|.|                        :|:....|.|      :|.......::||
  Fly   534 STSASPSVHHRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPGGQLWKTRLT 598

Human   614 RRNMSF----RFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTW--SMKTTSSMDP 672
            ....||    ||.:|              ...|||::.....|:.|...:.:|  ::.||...:.
  Fly   599 NIKNSFLGSPRFHRR--------------KMQVSADEVHLTPESSPELTKRSWFGNLITTEKDET 649

Human   673 GDM--------------------MREI-RKVLDANNCDYEQRERFLLFCVHGDGHA--ENLVQWE 714
            ..:                    |.|: ..|:...:...|.:.       :|:|..  :..|:::
  Fly   650 FTILVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKR-------NGNGPVMFQRHVKFQ 707

Human   715 ME---VCKLPRLS--LNGVRFKRISGTSIAFKNIASKIANEL 751
            ::   :||...::  |..:.|..:||....|:.|...|.:::
  Fly   708 VDISAICKQGDIADMLFALTFTLLSGNIRRFRRICEHIQSQV 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		STKc_MARK	55..307	CDD:270974	131/251 (52%)
		UBA_MARK3_4	325..367	CDD:270590	12/44 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		56/278 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		4/22 (18%)
		MARK1-3_C	654..751	CDD:213381	20/126 (16%)
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	132/252 (52%)
		UBA_BRSK	298..350	CDD:270525	14/51 (27%)