Protein Alignment MARK3 and Snrk

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Alignment Length: 739
• Identity: 226/739 - (30%)
• Similarity: 337/739 - (45%)
• Gaps: 151/739 - (20%)

Human    54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKL 118
            |.|.|.:|:|.|:||.||||||:.||.:||:|::|||:|:..|...||:|||.||::.|||:|:|
  Fly    18 GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHPNVVRL 82

Human   119 FEVIETEKTLYLIMEYASGGEVFDYLVAH-GRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAE 182
            :|||:|:..|||::|...||:::||::.| ..:.|:.||..||||:.|:.||||..:||||||.|
  Fly    83 YEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPE 147

Human   183 NLLLDADMN-IKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 246
            |::....:. :|:.||||||:|..|.||:|||||..|:|||:..|..||.|.||:||||||||.|
  Fly   148 NVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYML 212

Human   247 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGH 311
            |.|..||:..|..|....::..||.:|.::||||.:|:...||.:|.||.|:|:|....|
  Fly   213 VCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAW----- 272

Human   312 EEDELKPFVEPELDISD----------------------QKRIDIMVGMGYSQEEIQESLSKMKY 354
                |||..||:...|.                      ||.|:   |...|:|||.::|.|.||
  Fly   273 ----LKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMIN---GNIASKEEILQALDKNKY 330

Human   355 DEITATYLLLG-----RKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQK 414
            :.|||||.||.     |:..||            ..|.|..:|.:...|.:....|....|.::.
  Fly   331 NHITATYFLLAELRLRRRREEL------------AQKQRLLNDASMKVGDASRKLVPEKPSPTEA 383

Human   415 QR---RYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGK-GIAPASPMLGNA 475
            |:   ..|.:..||........|..:.|...|.::|:......:..:|||.: .:..:|.....:
  Fly   384 QKGGVPISINVTPAAQFANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTSSSRREAFS 448

Human   476 SNPNKADIPERKKSSTVPSSNT-----ASGGM---TRRNTYVCSERTTADRHSVIQ--------- 523
            .:|....|.||  ||:.|.:.|     |:.|:   :|....|..:.|.|  |.:.|
  Fly   449 DSPFSRSIHER--SSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLA--HKLKQMEKSAKIDE 509

Human   524 ------------------NGKENSTIPDQRTPV--ASTHSISSAA-------------------- 548
                              :..:|..:..:||.:  ..|.|.||:.
  Fly   510 DTLSGLKELEIGKLKPLPSSSKNPVLTHRRTKLNKIRTPSCSSSEASDDDTKTRNKKKINKFVGD 574

Human   549 TPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLT 613
            ||.|.|..|..:     |....:.:...| .||.|.|              .:.|..||..|...
  Fly   575 TPVRFRMHRRDS-----HDDSSDSQDQLY-PPPGSAS--------------NAGNFISKSGSVSG 619

Human   614 RRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMRE 678
            ::....::  :.|.......|...|.:|    :|..||:...:.......:..:|:...|:....
  Fly   620 KKEGQSQY--KEPNNKSDENRKSHSQKN----RKQHNKDHVDKHSHAERQLADSSTATTGNSTNR 678

Human   679 IRKVLDANNCD-------YEQRER 695
            .|::.::.:.|       ||.|.|
  Fly   679 RRRIRESQSLDRITEAQEYEMRHR 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		STKc_MARK	55..307	CDD:270974	125/253 (49%)
		UBA_MARK3_4	325..367	CDD:270590	20/68 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		54/290 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		6/22 (27%)
		MARK1-3_C	654..751	CDD:213381	8/49 (16%)
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	127/263 (48%)
		UBA_SNRK	296..338	CDD:270524	16/44 (36%)