DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MARK3 and grp

DIOPT Version :10

Sequence 1:NP_001122390.2 Gene:MARK3 / 4140 HGNCID:6897 Length:753 Species:Homo sapiens
Sequence 2:NP_477011.1 Gene:grp / 34993 FlyBaseID:FBgn0261278 Length:512 Species:Drosophila melanogaster


Alignment Length:667 Identity:164/667 - (24%)
Similarity:253/667 - (37%) Gaps:222/667 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 117
            :..:.|.:|:|:|.:.:|||..:..||..||:|::| .:.:|.:...:.:||.|.|:|...:|::
  Fly    19 VEGWTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVD-LKKHPDAANSVRKEVCIQKMLQDKHILR 82

Human   118 LFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAE 182
            .|.........|:.:|||:|||:||.:.....|.:.||:..|.|::|.:.|.||:.|.|||||.|
  Fly    83 FFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPE 147

Human   183 NLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILY 244
            |||||...|:||:|||.:..|...||   ||..||:.||.|||:.| |.|.....|:||.||||.
  Fly   148 NLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQ-KAYHAQPADLWSCGVILV 211

Human   245 TLVSGSLPFD--GQNLKELRERVLRGKYRI--PF-YMSTDCENLLKRFLVLNPIKRGTLEQIMKD 304
            |:::|.||:|  ..|..|.........:::  |: .:.|...:||::.|..:|..|.|||:.:..
  Fly   212 TMLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSKLDTLAISLLRKLLATSPGTRLTLEKTLDH 276

Human   305 RWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSS 369
            :|.|               :..:|.:|                     .||.:            
  Fly   277 KWCN---------------MQFADNER---------------------SYDLV------------ 293

Human   370 ELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQK--------QRRYSDHAGPAI 426
                 ||:::..:.                ||..|.||..||:..        .|.|.....|.:
  Fly   294 -----DSAAALEIC----------------SPKAKRQRLQSSAHLSNGLDDSISRNYCSQPMPTM 337

Human   427 PSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSST 491
            .|                  :|..:.|..||                            |.|.  
  Fly   338 RS------------------DDDFNVRLGSG----------------------------RSKE-- 354

Human   492 VPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFP 556
                   .||               ||.::.|..:             .::|.|..|..|.:.. 
  Fly   355 -------DGG---------------DRQTLAQEAR-------------LSYSFSQPALLDDLLL- 383

Human   557 RGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRF 621
                                             ||.::||:: .|.|.|.:|..::||..::.|:
  Fly   384 ---------------------------------ATQMNQTQN-ASQNYFQRLVRRMTRFFVTTRW 414

Human   622 ---IKRLPTEYERNGRYE---GSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIR 680
               ||||....||.|.|.   |....|:....|.||      ||..:..... .|| |.::.:.|
  Fly   415 DDTIKRLVGTIERLGGYTCKFGDDGVVTVSTVDRNK------LRLVFKAHII-EMD-GKILVDCR 471

Human   681 KVLDANNCDYEQRERFL 697
            .   :..|..|.:.||:
  Fly   472 L---SKGCGLEFKRRFI 485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MARK3NP_001122390.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
STKc_MARK 55..307 CDD:270974 96/259 (37%)
UBA_MARK3_4 325..367 CDD:270590 4/41 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..600 32/237 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..655 7/25 (28%)
MARK1-3_C 654..751 CDD:213381 10/44 (23%)
grpNP_477011.1 STKc_Chk1 20..279 CDD:270971 96/260 (37%)
Blue background indicates that the domain is not in the aligned region.

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