DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MARK3 and par-1

DIOPT Version :9

Sequence 1:NP_001122390.2 Gene:MARK3 / 4140 HGNCID:6897 Length:753 Species:Homo sapiens
Sequence 2:NP_995894.2 Gene:par-1 / 2768852 FlyBaseID:FBgn0260934 Length:1170 Species:Drosophila melanogaster


Alignment Length:791 Identity:432/791 - (54%)
Similarity:530/791 - (67%) Gaps:100/791 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     8 PTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCAD-----EQPHIGNYRLLKTIGKGNF 67
            ||||:.....|::|...   :..|||.:.......:.|.|.     .:.|||.|:|:||||||||
  Fly   203 PTVNKNVLSTHSAHPSA---IKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNF 264

Human    68 AKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIM 132
            ||||||:|:.||:||||||||||||||.|||||||||||||:|:||||||||:||||||||||||
  Fly   265 AKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIM 329

Human   133 EYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADF 197
            |||||||||||||.||||||||||.|||||||||||||||||:||||||||||||:::|||||||
  Fly   330 EYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADF 394

Human   198 GFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR 262
            |||||||.|.||||||||||||||||||||||||||||||||||||||||||||||||..|:|||
  Fly   395 GFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELR 459

Human   263 ERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDIS 327
            ||||||||||||||||||||||::||||||.||.:||.||.|:|:|.|.|||||||::||:.|::
  Fly   460 ERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLA 524

Human   328 DQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392
            |.|||:.:|.|||::.||:.|||:::||::.||||||||||::.::..|.|.|:|||..: ..:|
  Fly   525 DPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNI-SGND 588

Human   393 LNNSTG----QSPHHK-VQRSV--SSSQKQRRYSDHAGP--AIPSVVA--------YPKRSQT-- 438
            ...:.|    |||.|: |.||:  ||::..||.|...||  |..:|.|        .|..:..  
  Fly   589 AGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAA 653

Human   439 -STAD-----SDLK-EDGISSR--KSSGSAVGGKGIAPAS---PMLGNASNPNKADIPERKKSST 491
             |.||     |:.| ::.|.|.  |.:.:.:..:...|||   .||..|.....:....|..:..
  Fly   654 GSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKY 718

Human   492 VPSSNT-----ASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPD 551
            .|::..     .||.:.||:|.:..:.::.::.:||          ...|.:.....::||....
  Fly   719 DPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVI----------PAETNLFDRLRMASAVKSS 773

Human   552 RIRFPRGTASRSTFH-GQPRERRTAT--YNGPP-ASPSLSHEATPLSQTRSRGSTNLFSKLTSKL 612
            | .|||...|||||| ||.|.|....  |:|.. ||...||.          |..:.||||:|:.
  Fly   774 R-HFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHP----------GRMSFFSKLSSRF 827

Human   613 TRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMR 677
            ::|          ||                    ..::.||||.|||||||||||.:.|..:|:
  Fly   828 SKR----------PT--------------------IADEAAKPRVLRFTWSMKTTSPLMPDQIMQ 862

Human   678 EIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKN 742
            :||:|||.|||||||||||:|:|||||.:.::|||||:|||||||||||||||||||||||.|||
  Fly   863 KIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKN 927

Human   743 IASKIANELKL 753
            |||:||.:|||
  Fly   928 IASRIAFDLKL 938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MARK3NP_001122390.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 9/27 (33%)
STKc_MARK 55..307 CDD:270974 221/251 (88%)
UBA_MARK3_4 325..367 CDD:270590 23/41 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..600 72/269 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..655 1/22 (5%)
MARK1-3_C 654..751 CDD:213381 74/96 (77%)
par-1NP_995894.2 STKc_MARK 252..504 CDD:270974 221/251 (88%)
S_TKc 253..504 CDD:214567 221/250 (88%)
UBA_MARK_Par1 525..563 CDD:270522 21/37 (57%)
MARK1-3_C 839..936 CDD:213381 74/96 (77%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 457 1.000 Domainoid score I494
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55653
Inparanoid 1 1.050 737 1.000 Inparanoid score I598
Isobase 1 0.950 - 0 Normalized mean entropy S1552
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000311
OrthoInspector 1 1.000 - - otm41818
orthoMCL 1 0.900 - - OOG6_101232
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5061
SonicParanoid 1 1.000 - - X401
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.700

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