Protein Alignment MARK3 and kin1

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_596106.1
• Gene: kin1 / 2540792
• PomBaseID: SPBC4F6.06
• Length: 891
• Species: Schizosaccharomyces pombe
• Alignment Length: 895
• Identity: 253/895 - (28%)
• Similarity: 376/895 - (42%)
• Gaps: 229/895 - (25%)

Human     2 STRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPH-----IGNYRLLKT 61
            |:|.|||....| |.:|          :.|...||.      :..|||:|.     ||||.|.||
pombe    83 SSRKPLPASPSR-TRDH----------SLRVPVSGH------SYSADEKPRERRKVIGNYVLGKT 130

Human    62 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ---------------------KLFREVR 105
            ||.|:..|||:|.|:.||.:.||||:  |:|:|...:                     :..||..
pombe   131 IGAGSMGKVKVAHHLKTGEQFAIKIV--TRLHPDITKAKAAASAEATKAAQSEKNKEIRTVREAA 193

Human   106 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
            :..:|.||.|.:..:|..|....|::.|:..||::.||:::||::|||:||...|||.||:.|.|
pombe   194 LSTLLRHPYICEARDVYITNSHYYMVFEFVDGGQMLDYIISHGKLKEKQARKFVRQIGSALSYLH 258

Human   171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVD 235
            |..:||||||.||:|:....:|||.|||.||.:....:|.|||||..:|||||...:.|.|||||
pombe   259 QNSVVHRDLKIENILISKTGDIKIIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNAQPYIGPEVD 323

Human   236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
            |||.|::||.||.|.:|||.||:..|..::.:|....|.|:|:||:.||.|.||.:|:||.|||:
pombe   324 VWSFGIVLYVLVCGKVPFDDQNMSALHAKIKKGTVEYPSYLSSDCKGLLSRMLVTDPLKRATLEE 388

Human   301 IMKDRWINAGHE------EDELKPFVEPELDISDQKRIDIMVGMGYS-QEEIQESLSKM----KY 354
            ::...|:...:|      ..|..|...|    .|.:.|..|.|..:. .|:|...|:|:    .|
pombe   389 VLNHPWMIRNYEGPPASFAPERSPITLP----LDPEIIREMNGFDFGPPEKIVRELTKVISSEAY 449

Human   355 DEITATYLLLGRKSSELDASDSSSSSNLSLA------KVRPSSDLNNSTGQSPHHKVQ------- 406
            ..:..|....|..|:  |...|.....:..|      .:.||..:|.....:.|..:.
pombe   450 QSLAKTGFYSGPNSA--DKKKSFFEFRIRHAAHDIENPILPSLSMNTDIYDAFHPLISIYYLVSE 512

Human   407 ------------------RSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSR 453
                              .||.||..|....:...|.:|.||||             |.|..|.|
pombe   513 RRVYEKGGNWNRIAKTPVSSVPSSPVQPTSYNRTLPPMPEVVAY-------------KGDEESPR 564

Human   454 KSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADR 518
            .|.                 |.|...:..:|:.:..|..||:.::    .::|......|.::.|
pombe   565 VSR-----------------NTSLARRKPLPDTESHSPSPSATSS----IKKNPSSIFRRFSSRR 608

Human   519 HSVIQNGKENSTI------------------PDQRTPVASTHSISSAATPDRIRFPRGTASRSTF 565
            .   ||....||:                  |..:.||:..:.:.:          :....|||
pombe   609 K---QNKSSTSTLQISAPLETSQSPPTPRTKPSHKPPVSYKNKLVT----------QSAIGRST- 659

Human   566 HGQPRERRTA-------TYNGPPASPSLSHEATPLSQTRS------RGSTNLFSKLTSKLTRRNM 617
              ..||.|.|       :.|.....||.|:.|......|:      ||::....::::..|.|.
pombe   660 --SVREGRYAGISSQMDSLNMDSTGPSASNMANAPPSVRNNRVLNPRGASLGHGRMSTSTTNRQ- 721

Human   618 SFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENK--EAKPRSLRFTWSMKTTSSMDPGDMMREIR 680
                 |::..|...|    ...:|.::..|..:|  ..||..|:..:|:.|||:.....:.|::.
pombe   722 -----KQILNETMGN----PVDKNSTSPSKSTDKLDPIKPVFLKGLFSVSTTSTKSTESIQRDLI 777

Human   681 KVLDANNCDYEQ--------------RERFLLFCVH----------------------------G 703
            :|:...:.:|::              |.......||                            |
pombe   778 RVMGMLDIEYKEIKGGYACLYKPQGIRTPTKSTSVHTRRKPSYGSNSTTDSYGSVPDTVPLDDNG 842

Human   704 DGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
            :..|.||. :|:.:.|:|.|||.||.|.||||.|..:|.:||:|.|||||
pombe   843 ESPASNLA-FEIYIVKVPILSLRGVSFHRISGNSWQYKTLASRILNELKL 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		9/33 (27%)
		STKc_MARK	55..307	CDD:270974	117/272 (43%)
		UBA_MARK3_4	325..367	CDD:270590	11/46 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		52/291 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		4/24 (17%)
		MARK1-3_C	654..751	CDD:213381	36/138 (26%)
kin1	NP_596106.1	STKc_Kin1_2	123..395	CDD:270979	118/273 (43%)
		MARK_C_like	753..889	CDD:213377	34/136 (25%)