Protein Alignment MARK3 and par-1

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_001122967.2
• Gene: par-1 / 179912
• WormBaseID: WBGene00003916
• Length: 1216
• Species: Caenorhabditis elegans
• Alignment Length: 1174
• Identity: 446/1174 - (37%)
• Similarity: 545/1174 - (46%)
• Gaps: 456/1174 - (38%)

Human     9 TVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLA 73
            |.|.:::.:| :...|:   :..:|||.|| ||      |:..|:|.|:||||||||||||||||
 Worm    70 THNRKNSSSH-ARSTGQ---SGMSSRSAAR-RN------DQDVHVGKYKLLKTIGKGNFAKVKLA 123

Human    74 RHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGG 138
            :|::||.||||||||||.|||:|||||||||:|||.|:|||||||::|:|||:||||::||||||
 Worm   124 KHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGG 188

Human   139 EVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEF 203
            ||||||||||||||||||:|||||||||||.|.|.|:||||||||||||.|||||||||||||.|
 Worm   189 EVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTF 253

Human   204 TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 268
            ::|.|||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
 Worm   254 SLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 318

Human   269 KYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID 333
            |||||||||||||||||:|||:||.:|.:|:.||||||:|.|:|:||||||:||..|..|::||:
 Worm   319 KYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQIDEQRIE 383

Human   334 IMV---GMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD-SSSSSNLSLAKVRPSSDLN 394
            .::   .:|:::..|.||:.|.|:::|.|||||||.:.|::|||: :.:.|.||.:.:..||.|
 Worm   384 KLIQIFQLGFNKAAILESVEKEKFEDIHATYLLLGERKSDMDASEITMAQSLLSHSSINVSSSL- 447

Human   395 NSTGQSP------HHKVQRSVS-SSQKQRRYSDH----------AGPAIPSVVAYPKRSQTSTAD 442
               ||.|      .|....|.| ||....|||..          ||.|:.|.....|..|:|.|.
 Worm   448 ---GQHPAGVITREHVTSSSASGSSASPSRYSRSSATATGASITAGSALASAANAQKHQQSSAAP 509

Human   443 SDLKEDGISSRKSS-----GSAVGGKGI------------------------------APAS--- 469
            |   ....|||:||     .:|.||..:                              .|:|
 Worm   510 S---SGSSSSRRSSQNDAAATAAGGTVVMSGTRHGGVQMRAQPTSRQATISLLQPPSYKPSSNTT 571

Human   470 -----PMLGN--------ASNPNKADIPERK----------KSSTVPSSNTASGGMTRRNTYVCS 511
                 |.|.|        |:.|:......||          .|:.|....||:|.:...|..:.|
 Worm   572 QIAQIPPLFNRNSTATSSAAQPSTGITGTRKIADPKGRIPLNSTAVQGHRTATGAVAANNGGIPS 636

Human   512 ERTTA------------------------------------------------------------ 516
            .|..|
 Worm   637 HRDHAQQQQYMNQLTSSTMMSKLINKTPAAGGTAATSSSSSSSATSTAPLQKSGSQISHAPTEPV 701

Human   517 ------DRHSVIQNG----------------------------------KENSTIPDQRTP---- 537
                  :.:|..|||                                  |.:|..|.:..|
 Worm   702 IREDDDENNSENQNGNVPLIGGVGPQTSPAVQVPTEDATSSSDKEQQQQKASSETPKESKPSMIH 766

Human   538 -----------------------------VAS--------------------------------- 540
                                         ||:
 Worm   767 QSPSMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMGASSGGAAAA 831

Human   541 ------------------------------------------THSISSAATPDRIR--------- 554
                                                      ||:.|.:.||...:
 Worm   832 ASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLTHNASFSVTPSSYQIPTSTAVNV 896

Human   555 -------------FPRGTASRSTFHG--------------------------------------- 567
                         |||.|.:|.||||
 Worm   897 TSTGMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVSIGATGPSANNAEATIW 961

Human   568 ----------------QPR------------------ERRTATYNGP------------PASPSL 586
                            |||                  .|.|:.|..|            ||:||.
 Worm   962 SKLSKLTRRSSTAAAHQPRGSSLHHSMSMTQSPSQLSSRFTSNYVAPIVRSKPPAPVSTPAAPSA 1026

Human   587 SHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYE---GSSRNVSAEQKD 648
            :   .|:....|...|.:..:...||:...|:.|      .::.|....:   |.:..:.|.|..
 Worm  1027 T---APIPVIVSPAVTKMLKENRRKLSEEAMAIR------RDHNRESMTQPVSGRAGTIGASQGQ 1082

Human   649 ENKEA-----------------------------KPRSLRFTWSMKTTSSMDPGDMMREIRKVLD 684
            :...|                             ||||||||||||||||:.|.|||||||||||
 Worm  1083 QTAAALAAIREQSGPIAPGAGQVAPSLPIHEGDVKPRSLRFTWSMKTTSSLAPDDMMREIRKVLD 1147

Human   685 ANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIAN 749
            ||.||||||||:::.|||||.:.::|||||||||||||||||||||||||||||.|||||||||.
 Worm  1148 ANGCDYEQRERYMILCVHGDPNTDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIGFKNIASKIAQ 1212

Human   750 ELKL 753
            ||.|
 Worm  1213 ELNL 1216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		6/26 (23%)
		STKc_MARK	55..307	CDD:270974	215/251 (86%)
		UBA_MARK3_4	325..367	CDD:270590	18/44 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		92/623 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		4/54 (7%)
		MARK1-3_C	654..751	CDD:213381	81/96 (84%)
par-1	NP_001122967.2	STKc_MARK	105..357	CDD:270974	215/251 (86%)
		MARK1-3_C	1117..1214	CDD:213381	81/96 (84%)