Protein Alignment MARK3 and Mark3

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: XP_006515574.1
• Gene: Mark3 / 17169
• MGIID: 1341865
• Length: 806
• Species: Mus musculus
• Alignment Length: 806
• Identity: 731/806 - (90%)
• Similarity: 739/806 - (91%)
• Gaps: 53/806 - (6%)

Human     1 MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKG 65
            ||||||||||||||||||.|||||||||||||.||||||||||||||||||||||||||||||||
Mouse     1 MSTRTPLPTVNERDTENHISHGDGRQEVTSRTGRSGARCRNSIASCADEQPHIGNYRLLKTIGKG 65

Human    66 NFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYL 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 NFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYL 130

Human   131 IMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIA 195
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse   131 IMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIA 195

Human   196 DFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 260
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 DFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 260

Human   261 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELD 325
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Mouse   261 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELD 325

Human   326 ISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPS 390
            |||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||:
Mouse   326 ISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPN 390

Human   391 SDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKS 455
            |||:||||||||||.|||||||||||||||||||||||||||||||||||||||||||||.||||
Mouse   391 SDLSNSTGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGIPSRKS 455

Human   456 SGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHS 520
            |.||||||||||||||||||.|||||||||||||..||||||||||||||||||||||..|||||
Mouse   456 SSSAVGGKGIAPASPMLGNAGNPNKADIPERKKSPAVPSSNTASGGMTRRNTYVCSERCAADRHS 520

Human   521 VIQNGKENS-----------------------------------------------------TIP 532
            |||||||||                                                     .||
Mouse   521 VIQNGKENSLTEVFAYAASPASLCATSTCRLRHQRSMSVSASGHPKMVLPPIDSEGDTFKAIAIP 585

Human   533 DQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTR 597
            |:|||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 DERTPVASTHSISSATTPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTR 650

Human   598 SRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTW 662
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||:|||||||||||
Mouse   651 SRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSSEQKDENREAKPRSLRFTW 715

Human   663 SMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNG 727
            ||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   716 SMKTTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNG 780

Human   728 VRFKRISGTSIAFKNIASKIANELKL 753
            ||||||||||||||||||||||||||
Mouse   781 VRFKRISGTSIAFKNIASKIANELKL 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		32/34 (94%)
		STKc_MARK	55..307	CDD:270974	248/251 (99%)
		UBA_MARK3_4	325..367	CDD:270590	41/41 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		216/282 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		20/22 (91%)
		MARK1-3_C	654..751	CDD:213381	95/96 (99%)
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	248/251 (99%)
		UBA_MARK3_4	325..367	CDD:270590	41/41 (100%)
		MARK1-3_C	707..804	CDD:213381	95/96 (99%)