Protein Alignment MARK3 and Mark3

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: XP_006240625.1
• Gene: Mark3 / 170577
• RGDID: 619883
• Length: 806
• Species: Rattus norvegicus
• Alignment Length: 806
• Identity: 727/806 - (90%)
• Similarity: 737/806 - (91%)
• Gaps: 53/806 - (6%)

Human     1 MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKG 65
            ||||||||||||||||||.|||||||||||||.||||||||||||||||||||||||||||||||
  Rat     1 MSTRTPLPTVNERDTENHISHGDGRQEVTSRTGRSGARCRNSIASCADEQPHIGNYRLLKTIGKG 65

Human    66 NFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYL 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 NFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYL 130

Human   131 IMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIA 195
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
  Rat   131 IMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIA 195

Human   196 DFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 260
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 DFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 260

Human   261 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELD 325
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||:|||||||||||
  Rat   261 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEEELKPFVEPELD 325

Human   326 ISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPS 390
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
  Rat   326 ISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPS 390

Human   391 SDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKS 455
            |||:||||||||||.||||||||||||||||||||||||||||||||||||||||||||:.||||
  Rat   391 SDLSNSTGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGVPSRKS 455

Human   456 SGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHS 520
            ..||||||||||||||||||||||||||||||||..|||||.||||||||||||||||..|||||
  Rat   456 GSSAVGGKGIAPASPMLGNASNPNKADIPERKKSPAVPSSNAASGGMTRRNTYVCSERCAADRHS 520

Human   521 VIQNGKENS-----------------------------------------------------TIP 532
            |||||||:|                                                     |.|
  Rat   521 VIQNGKESSLTEVFAYAASPASLCATSTCRLRHQRSMSVSASGHPKMVLPPIDSEGDTFKAITTP 585

Human   533 DQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTR 597
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 DQRTPVASTHSISSATTPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTR 650

Human   598 SRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTW 662
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||:|||||||||||
  Rat   651 SRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSSEQKDENREAKPRSLRFTW 715

Human   663 SMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNG 727
            ||||||||||.|||||||||||||.|||||||||||||||||||||:||||||||||||||||||
  Rat   716 SMKTTSSMDPSDMMREIRKVLDANTCDYEQRERFLLFCVHGDGHAESLVQWEMEVCKLPRLSLNG 780

Human   728 VRFKRISGTSIAFKNIASKIANELKL 753
            ||||||||||||||||||||||||||
  Rat   781 VRFKRISGTSIAFKNIASKIANELKL 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		32/34 (94%)
		STKc_MARK	55..307	CDD:270974	248/251 (99%)
		UBA_MARK3_4	325..367	CDD:270590	41/41 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		215/282 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		20/22 (91%)
		MARK1-3_C	654..751	CDD:213381	93/96 (97%)
Mark3	XP_006240625.1	STKc_MARK	55..307	CDD:270974	248/251 (99%)
		UBA_MARK3_4	325..367	CDD:270590	41/41 (100%)
		MARK1-3_C	707..804	CDD:213381	93/96 (97%)