Protein Alignment MARK3 and mark3

DIOPT Version :10

• Sequence 1: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Sequence 2: XP_031747282.1
• Gene: mark3 / 100329119
• XenbaseID: XB-GENE-867495
• Length: 794
• Species: Xenopus tropicalis
• Alignment Length: 807
• Identity: 690/807 - (85%)
• Similarity: 711/807 - (88%)
• Gaps: 67/807 - (8%)

Human     1 MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKG 65
            ||||||||||||||||||||||||||:|.||:.|.|||.||||||||||||||||||||||||||
 Frog     1 MSTRTPLPTVNERDTENHTSHGDGRQDVLSRSGRQGARSRNSIASCADEQPHIGNYRLLKTIGKG 65

Human    66 NFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYL 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    66 NFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYL 130

Human   131 IMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIA 195
            :|||||||||||||||||||||||||:|||||||||||||||.||||||||||||||||||||||
 Frog   131 VMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIA 195

Human   196 DFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 260
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 DFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 260

Human   261 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELD 325
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
 Frog   261 LRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSKRGTLEQIMKDRWINAGHEEDELKPFVEPELD 325

Human   326 ISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPS 390
            ||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||:
 Frog   326 ISDQKRIDIMVGMGYSREEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPN 390

Human   391 SDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKS 455
            ||||||:||||||| .||:||||||||||||||||:|||.||||||||||.|:|||::...||||
 Frog   391 SDLNNSSGQSPHHK-GRSISSSQKQRRYSDHAGPAVPSVTAYPKRSQTSTTDNDLKDEVGQSRKS 454

Human   456 SGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHS 520
            |.:   |:|:.|.||||||||||||||||||||||.||:||:.|.|||||||||||||...||||
 Frog   455 SST---GRGVTPPSPMLGNASNPNKADIPERKKSSVVPTSNSTSSGMTRRNTYVCSERAPTDRHS 516

Human   521 VIQNGKENS------------------------------------------------------TI 531
            |||||||||                                                      ||
 Frog   517 VIQNGKENSLTGIFTYATSPASVCAISSIFARLRHPKSMSMSASRHSEMLPPIASEGDNFGPATI 581

Human   532 PDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQT 596
            |||||.|||||||:|..||||:|||||||||||||||.|||||||||||||||||||||||||||
 Frog   582 PDQRTSVASTHSITSTTTPDRMRFPRGTASRSTFHGQLRERRTATYNGPPASPSLSHEATPLSQT 646

Human   597 RSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFT 661
            ||||||||||||||||||         |||||.||||||||||||||.:|||||||:||||||||
 Frog   647 RSRGSTNLFSKLTSKLTR---------RLPTESERNGRYEGSSRNVSGDQKDENKESKPRSLRFT 702

Human   662 WSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLN 726
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   703 WSMKTTSSMDPNDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLN 767

Human   727 GVRFKRISGTSIAFKNIASKIANELKL 753
            |||||||||||||||||||||||||||
 Frog   768 GVRFKRISGTSIAFKNIASKIANELKL 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		30/34 (88%)
		STKc_MARK	55..307	CDD:270974	246/251 (98%)
		UBA_MARK3_4	325..367	CDD:270590	40/41 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600		192/283 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655		19/22 (86%)
		MARK1-3_C	654..751	CDD:213381	95/96 (99%)
mark3	XP_031747282.1	STKc_MARK	55..307	CDD:270974	246/251 (98%)
		UBA_MARK3_4	325..367	CDD:270590	40/41 (98%)
		MARK1-3_C	695..792	CDD:213381	95/96 (99%)