Protein Alignment ARSD and Sgsh

DIOPT Version :10

• Sequence 1: NP_001660.2
• Gene: ARSD / 414
• HGNCID: 717
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_650760.1
• Gene: Sgsh / 42266
• FlyBaseID: FBgn0038660
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 615
• Identity: 138/615 - (22%)
• Similarity: 209/615 - (33%)
• Gaps: 175/615 - (28%)

Human    22 LFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAA 86
            :|...|:..|     :|...|:||::|||.|. :.|.|.|...:|||:|.||:.|:.......:.
  Fly     7 IFTLWLIAGC-----SAGPQNVLLLLADDAGF-ESGAYLNKFCQTPNLDALAKRGLLFNNAFTSV 65

Human    87 PLCTPSRAAFLTGRHSFRSGM-DASNGYRALQWNAGSGGLPE--NETTFARILQQHGYATGLIGK 148
            ..|:|||:..|||:....||| ....|.........:|.||.  .:.:..|||      :|:|||
  Fly    66 SSCSPSRSQLLTGQAGHSSGMYGLHQGVHNFNVLPDTGSLPNLIRDQSGGRIL------SGIIGK 124

Human   149 WHQGVNCASRGDHCHHPLNHGFDYF---------YGMPFTLTNDCDPGRPPEVDAALRAQLWGYT 204
            .|.|.....|.|.......|..:..         |...| |....|..:|
  Fly   125 KHVGAANNFRFDFEQTEEQHSINQIGRNITRMKEYARQF-LKQAKDEKKP--------------- 173

Human   205 QFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCIL--MRNHDVTEQ 267
            .||.:|   ......||.       :|...|..|..:.|.....|.:..|..|.  .||.||
  Fly   174 FFLMVG---FHDPHRCGH-------ITPQFGEFCERWGSGEEGMGSIPDWKPIYYDWRNLDV--- 225

Human   268 PMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWL 332
            |..|..|..:..:.|..|:                                      .:..:|..
  Fly   226 PAWLPDTDVVRQELAAQYM--------------------------------------TISRLDQG 252

Human   333 IGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFH 397
            :|.:|..:|..|:.:.|...:|||:|....        ||...:|         |.|||.|.|..
  Fly   253 VGLMLKELEAAGVADQTLVIYTSDNGPPFP--------GGRTNLY---------EHGIRSPLIIS 300

Human   398 WPG------VLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAE-------- 448
            .|.      ...|..|     ||:|::|:|:..:....|.|..|.|.|::|:|:...
  Fly   301 SPNKEDRHHEATAAMV-----SLLDIYPSVMDALQIPRPNDTKIVGRSILPVLREEPPIKESDSV 360

Human   449 --ARSAHEFLFHYCGQHLHAARWHQKDSGSVW------KVHYTTPQFHPEGAGACYGRGVCPCSG 505
              :.|.||....|..:.:...|:....:.:.|      :..||:|.|. :...|...:...|...
  Fly   361 FGSHSYHEVTMAYPMRMVRNRRYKLIHNINYWADFPIDQDFYTSPTFQ-QILNATLRKQTLPWYR 424

Human   506 EGVTHHRPP--LLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQTLSPVPQQFSMSNIL 568
            ..:.:::.|  .|:|:..||.|...|                |..:::..||..:.:|.....:.
  Fly   425 SLLQYYQRPEWELYDIKTDPLERFNL----------------ADKAKYNGTLKQLREQLFDWQVA 473

Human   569 WK-PWL---------------QPCC---GH 579
            .| ||.               ||.|   ||
  Fly   474 TKDPWRCAPHAVLQEQGVYKDQPVCLTLGH 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARSD	NP_001660.2	ALP_like	40..563	CDD:474031	126/560 (23%)
Sgsh	NP_650760.1	SGSH	22..471	CDD:293751	126/561 (22%)