DRSC/TRiP Functional Genomics Resources

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Protein Alignment Elp1 and Elp1

DIOPT Version :9

Sequence 1:NP_001262478.1 Gene:Elp1 / 41399 FlyBaseID:FBgn0037926 Length:1256 Species:Drosophila melanogaster
Sequence 2:NP_080355.2 Gene:Elp1 / 230233 MGIID:1914544 Length:1333 Species:Mus musculus


Alignment Length:1343 Identity:422/1343 - (31%)
Similarity:676/1343 - (50%) Gaps:175/1343 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MRNLKLRYC---KELNAVAHPQHLLLQPE----LNGGASDIYFVVADNKIYAVQESGDVRLKVIA 58
            ||||||...   :::.|...||...|:.|    |.|....:      .::..|:......:.::|
Mouse     1 MRNLKLHRTLEFRDIQAPGKPQCFCLRAEQGTVLIGSERGL------TEVDPVRREVKTEISLVA 59

  Fly    59 D--LPD-----IVGVEFLQLDNAICVASGAGEVILVDPQT------GATSEGTFCDVGIESMAWS 110
            :  ||:     |||::.|....::|||:.:|:||:.:..|      |:.:.      ||..|:||
Mouse    60 EGFLPEDGSGCIVGIQDLLDQESVCVATASGDVIVCNLSTQQLECVGSVAS------GISVMSWS 118

  Fly   111 PNQEVVAFVTRTHNVVLMTSTFDVIAEQPLDAELDPDQQFVNVGWGKKETQFHGSEGKQAAKQKE 175
            |:||::...|....:::||..|:||||:.:..:...:.:||.||||.|:||||||||:..|...:
Mouse   119 PDQELLLLATAQQTLIMMTKDFEVIAEEQIHQDDFGEGKFVTVGWGSKQTQFHGSEGRPTAFPVQ 183

  Fly   176 SDSTFIRDEQELNQFTPQD---VSISWRGDGEFFVVSYVAAQL-GRTFKVYDSEGKLNHTAEKSA 236
            .....:          |.|   ..|:|||||::|.||.|..|. .|..:|::.|..|..|:|...
Mouse   184 LPENAL----------PWDDRRPHITWRGDGQYFAVSVVCRQTEARKIRVWNREFALQSTSESVP 238

  Fly   237 NLKDSVVWRPTGNWIAVPQQFPNKSTIALFEKNGLRHRELVLPFDLQEEPVVQLRWSEDSDILAI 301
            .|..::.|:|:|:.||..|..||:..:..||||||.|....|||...|..|..|.|:.||.:|||
Mouse   239 GLGPALAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHGHFTLPFLKDEVKVNDLLWNADSSVLAI 303

  Fly   302 --RTCAKEEQR-----VYLYTIGNYHWYLKQVLIFEQA--DPLALLHWD--TRCGAEHTLHVLKE 355
              ....||:..     |.|:|:|||||||||.|.|...  :.:..|.||  |.|    .||||..
Mouse   304 WLEDLPKEDSSTLKSYVQLWTVGNYHWYLKQSLPFSTTGKNQIVSLLWDPVTPC----RLHVLCT 364

  Fly   356 SGKHLVYRWAFAVDRN--NSI-----VGVIDGKRLLLTDFDEAIVPPPMSKIVLKFETYIN---- 409
            ..::|...|.:..||:  ||.     |.||||.|:|:|.|.:.:|||||....|.....:|    
Mouse   365 GWRYLCCDWHWTTDRSSGNSANDLANVAVIDGNRVLVTVFRQTVVPPPMCTYRLLIPHPVNQVIF 429

  Fly   410 --------AFISHGTSLWVYTCDRKIYLNEHIHTLG-------------KELQKPIMLM------ 447
                    |.:.....:.||.|..|..::..: .||             ..|:|...:.      
Mouse   430 SAHLGNDLAVLDASNQISVYKCGDKPNMDSTV-KLGAVGGNGFKVPLTTPHLEKRYSIQFGNNEE 493

  Fly   448 -PDAELSGLHLANLTHFSPHYLLA---THSSAGS-TRLLLLSYKDNDNKPGEWFYRVHSSVRING 507
             .:.|::.|.|:.||.......||   :|||:.| ...|.:::.:.|.:.|:  ..|.|||.::|
Mouse   494 EEEEEVNALQLSFLTWVEDDTFLAISYSHSSSQSIIHHLTVTHSEVDEEQGQ--LDVSSSVTVDG 556

  Fly   508 LVNAVAVAPYAMNEFYVQTVNNGHTYEV-----SLKADKTLKVERSYVQLHEPADQIDWVIVKG- 566
            :|  :.:...:..:.....:.:|...:.     ||..:.....|...|:...|..|::...:.| 
Mouse   557 VV--IGLCCCSKTKSLAVQLADGQVLKYLWESPSLAVEPWKNSEGIPVRFVHPCTQMEVATIGGE 619

  Fly   567 -CIWDGYTGALVTLRNQHLLHIDGYRIGEDVTSFCVVTNYLVYT------QLNAMHFVQLDDRRQ 624
             |:        :.|.::....|:...:..::|||.|..::|:.|      |:.::....|...:.
Mouse   620 ECV--------LGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQVFSLSGASLKMLQA 676

  Fly   625 VAS----------RNIERGAKIVTAVARKARVVLQLPRGNLEAICPRVLVLELVGDLLERGKYQK 679
            ..|          |.:|||::|||.|.:..:::||:||||||.:..|.|||..:...|::..:::
Mouse   677 ALSGSHEASGEILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKE 741

  Fly   680 AIEMSRKQRINLNIIFDHDVKRFVSSVGAFLNDINEPQWLCLFLSELQNEDFTKGMYSSNYDASK 744
            |.|..||.|||||:|.||:.|.|:.:|..|:..|:....:.||.:||:.||.||.||......|.
Mouse   742 AFECMRKLRINLNLIHDHNPKVFLENVETFVKQIDSVNHINLFFTELREEDVTKTMYPPPITKSV 806

  Fly   745 Q--TYPSDYRVDQKVEYVCRLLEQQMNRFVSR-FRLPLITAYVKLGCLEMALQVIWKEQQEDASL 806
            |  |:|.    .:|::.:|..:...|.....| |.|.::|::||....|:.: |:.|.|:...:|
Mouse   807 QVSTHPD----GKKLDLICDAMRAAMEAINPRKFCLSILTSHVKKTTPELEI-VLQKVQELQGNL 866

  Fly   807 --------ADQLLQHLLYLVDVNDLYNVALGTYDFGLVLFVAQKSQKDPKEFLPYLNDLKALPID 863
                    .::.|::||.|||||:|:|.:||||||.|||.||:||||||||:||:||.||.:..:
Mouse   867 PFDPESVSVEEALKYLLLLVDVNELFNHSLGTYDFNLVLMVAEKSQKDPKEYLPFLNTLKKMETN 931

  Fly   864 YRKFRIDDHLKRYTSALSHLAACGEQHYEEALEYIRKHGLYTDGLAFYREHIEFQKNIYVAYADH 928
            |::|.||.:||||..||.||:.||.:::.|.|..|:...||.:.|..||......:.:.:||.:|
Mouse   932 YQRFTIDKYLKRYEKALGHLSKCGPEYFTECLNLIKDKNLYKEALKLYRPDSPQYQAVSMAYGEH 996

  Fly   929 LRAIAKLDNASLMYERGGQLQQALLSAKHTLDWQRVLVLAKKLSEPLDQV---AQSLVGPLQQQG 990
            |......:.|.|::.|.|..::||.:......||:.|.:|.:|....|:|   |::|.|.|.:|.
Mouse   997 LMQEHLYEPAGLVFARCGAQEKALEAFLACGSWQQALCVAAQLQMSKDKVAGLARTLAGKLVEQR 1061

  Fly   991 RHMEAYELVKEHCQDRKRQFDVLLEGHLYSRAIYEAGLED--DDVSEKIAPALLAYGVQLESSLQ 1053
            :|.||..:::::.||.:....:||||..:..|:......|  |.:...:.|::|.........|.
Mouse  1062 KHSEAATVLEQYAQDYEEAVLLLLEGSAWEEALRLVYKYDRVDIIETSVKPSILEAQKNYMDFLD 1126

  Fly  1054 ADLQLFLDYKQRLLDIRRNQAKSGEGYIDTDV-NLKEVDLLSDTTSL-----HSSQYSGTSRRTG 1112
            ::...|:.:|.||..:|..:.::.:.::|.:| :..|.||.|:|:|:     .|.:||.::.|. 
Mouse  1127 SETATFIRHKNRLQVVRALRRQAPQVHVDHEVAHGPESDLFSETSSIMSGSEMSGRYSHSNSRI- 1190

  Fly  1113 KTFRSSKNRRKHERKLFSLKPGNPFEDIALIDALHNHVTKIAQQQQPVRDTCKALLQLANAADAD 1177
             :.||||||||.|||..|||.|:|.|.:||::||    :::.|..:.::|..:|:|::....:.:
Mouse  1191 -SARSSKNRRKAERKKHSLKEGSPLEGLALLEAL----SEVVQSVEKLKDEVRAILKVLFLFEFE 1250

  Fly  1178 PLAAALQREFKTLLQAVDAALDEIWTPELRGNGLMADHLTGPN 1220
            ..|..|||.|::.||.::.|:.|||||  .|.......:.||:
Mouse  1251 EQAKELQRAFESTLQLMERAVPEIWTP--AGQQSSTTPVLGPS 1291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Elp1NP_001262478.1 IKI3 1..887 CDD:282600 317/997 (32%)
COG5290 13..1207 CDD:227610 413/1313 (31%)
Elp1NP_080355.2 IKI3 1..955 CDD:282600 337/1065 (32%)
COG5290 71..1276 CDD:227610 401/1259 (32%)
WD40 repeat 112..147 CDD:293791 10/34 (29%)
WD40 repeat 192..231 CDD:293791 17/42 (40%)
TPR 875..1101 CDD:223533 66/236 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1175..1209 13/33 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846072
Domainoid 1 1.000 409 1.000 Domainoid score I697
eggNOG 1 0.900 - - E1_COG5290
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2699
Inparanoid 1 1.050 551 1.000 Inparanoid score I1125
Isobase 1 0.950 - 0.993157 Normalized mean entropy S3846
OMA 1 1.010 - - QHG55001
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005043
OrthoInspector 1 1.000 - - oto93859
orthoMCL 1 0.900 - - OOG6_102646
Panther 1 1.100 - - LDO PTHR12747
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R390
SonicParanoid 1 1.000 - - X3567
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.740

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