Protein Alignment Csk and RIPK2

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_003812.1
• Gene: RIPK2 / 8767
• HGNCID: 10020
• Length: 540
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 64/268 - (23%)
• Similarity: 115/268 - (42%)
• Gaps: 64/268 - (23%)

  Fly   823 KVAVKML-----------KDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKG 876
            :||||.|           ||      .|.||.::.......::..:|:....:.|.:|||||..|
Human    43 QVAVKHLHIHTPLLDSERKD------VLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNG 101

  Fly   877 SLVDYLRSRGRQHITKKDQIIF------AYDTASGMEYLE--AKKVVHRDLAARNVLISEDCVAK 933
            ||.:.|..:     |:...:.:      .::.|.|:.||.  ...::|.||..:|:|:..:...|
Human   102 SLNELLHRK-----TEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVK 161

  Fly   934 VSDFGLAREECYNLDVGKL--------PIKWTAPEALKNG---RFSNKSDMWSFGILLWEIYSFG 987
            ::||||::....:|...:.        .|.:..||..:.|   |.|.|.|::|:.::.||:.|
Human   162 IADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLS-- 224

  Fly   988 RVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYE---------------MMRQAWDLNPAKRPTF 1037
                .:.|..||...:::.|.:.  :|..|.|.|               ::...|..||.:||:|
Human   225 ----RKQPFEDVTNPLQIMYSVS--QGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSF 283

  Fly  1038 AELKVKLQ 1045
            .:..::|:
Human   284 LKCLIELE 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190
		PTKc_Csk_like	793..1047	CDD:270635	64/268 (24%)
RIPK2	NP_003812.1	STKc_RIP2	20..303	CDD:270928	64/268 (24%)
		Helix alphaC. /evidence=ECO:0000269|PubMed:28545134	65..73		2/7 (29%)
		Activation segment (AS). /evidence=ECO:0000269|PubMed:28545134	167..193		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..369
		CARD_RIP2_CARD3	438..524	CDD:176764