DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and RKF1

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_174268.7	Gene:	RKF1 / 839853	AraportID:	AT1G29750	Length:	1021	Species:	Arabidopsis thaliana

Alignment Length:	321	Identity:	99/321 - (30%)
Similarity:	144/321 - (44%)	Gaps:	62/321 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 CLPKLGKQEFCINSKDFVDKGWVIPEAELQLRE------------SIGKGEFGDVMLGILRNEK- 823
            |||:.|:|.     ||..::  .:|.....||:            .||:|.||.|..|:|.:.:
plant   648 CLPRCGRQR-----KDPYEE--ELPSGTFTLRQIKFATDDFNPTNKIGEGGFGAVFKGVLADGRV 705

  Fly   824 VAVKML--KDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRG 886
            ||||.|  |.....::||.|...::.|:|.||||..|.......|.|..|||...||...|.|
plant   706 VAVKQLSSKSRQGNREFLNEIGAISCLQHPNLVKLHGFCVERAQLLLAYEYMENNSLSSALFS-- 768

  Fly   887 RQHITKKDQIIFAYDT--------ASGMEYLEAK---KVVHRDLAARNVLISEDCVAKVSDFGLA 940
                .|..||...:.|        |.|:.:|..:   |.||||:.|.|:|:.:|...|:||||||
plant   769 ----PKHKQIPMDWPTRFKICCGIAKGLAFLHEESPLKFVHRDIKATNILLDKDLTPKISDFGLA 829

  Fly   941 R---EECYNLDVGKL--PIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVV 1000
            |   ||..::.. |:  .|.:.|||....|..:.|:|::|||:|:.||.: |......:...|.|
plant   830 RLDEEEKTHIST-KVAGTIGYMAPEYALWGYLTFKADVYSFGVLVLEIVA-GITNSNFMGAGDSV 892

  Fly  1001 -------KHVEVGYKME-APEGCPPEIYEMMRQA--------WDLNPAKRPTFAELKVKLQ 1045
                   :.||.|:.|: ..|...||:.....:|        ...:|..||..:|:...|:
plant   893 CLLEFANECVESGHLMQVVDERLRPEVDRKEAEAVIKVALVCSSASPTDRPLMSEVVAMLE 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	3/4 (75%)
		PTKc_Csk_like	793..1047	CDD:270635	92/300 (31%)
		STYKc	800..1044	CDD:214568	90/290 (31%)
RKF1	NP_174268.7	LRR	112..395	CDD:227223
		leucine-rich repeat	125..147	CDD:275380
		leucine-rich repeat	148..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..218	CDD:275380
		leucine-rich repeat	219..242	CDD:275380
		leucine-rich repeat	243..266	CDD:275380
		leucine-rich repeat	267..287	CDD:275380
		leucine-rich repeat	291..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		leucine-rich repeat	338..356	CDD:275380
		Malectin	417..604	CDD:288557
		STYKc	686..952	CDD:214568	88/273 (32%)
		STKc_IRAK	687..955	CDD:270968	89/275 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000