DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and SRF1

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_565489.2	Gene:	SRF1 / 816618	AraportID:	AT2G20850	Length:	775	Species:	Arabidopsis thaliana

Alignment Length:	689	Identity:	138/689 - (20%)
Similarity:	223/689 - (32%)	Gaps:	236/689 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 PAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHHRENNVHPIQAGAAA 457
            |:|.|.         |.|...           |..:|...|||  |:                |:
plant   255 PSPSPE---------TPPSPT-----------SPKRPFFGPPS--PN----------------AS 281

  Fly   458 ALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQ 522
            |.|..:|      :.|..|:|.|..|:...::...|:      ::....|||..|:.........
plant   282 AGHGQAH------VRSPPSDHHPSRPTPQGKEDSFTS------KRIIWISILGAFSFVVLALVCL 334

  Fly   523 PAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALPPKSLAL 587
            ..|.:.:.....     ::|..:.||              :|....|:.|.......|||
plant   335 LCGRKCLRKRED-----SEQLSKPHL--------------TSEYGRAREGSRSNASMLPP----- 375

  Fly   588 SGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSL--------HSFDINGVTAGSGVNA 644
                  ||..     ...:.::|...||.:.....|...|:        |..|:||
plant   376 ------SNTF-----NKDKEARPKERVGGASKLHGGAERSVGSESKQESHEIDMNG--------- 420

  Fly   645 SSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGS----ITRDEAEHLLQPREDGL 705
                                               |||...|.|    |.|..|: ..:|.|..
plant   421 -----------------------------------NAMDLMHPSSIPPIKRVIAK-ATEPAEAS- 448

  Fly   706 FLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLI 770
             |.|.::...|..|       .|:|:.|..|:........|.....|.|.:.|.|:..|   ..:
plant   449 -LKRTTSKSHGPLT-------AVKHFTVASLQQHTNSFSHENLIGTGMLGSVYRAELPG---GKL 502

  Fly   771 KCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVKMLKDEGAV 835
            ..:.||.|:.               |..|                               :||
plant   503 FAVRKLDKKS---------------PNHE-------------------------------EEG-- 519

  Fly   836 QKFLAEASVMTTLEHDNLVKFIGLVFTSKH--LYLVTEYMSKGSLVDYLR--SRGRQHITKKDQI 896
             |||...:.:..:.|.|:|:.:|  |.|:|  ..|:.||...|:|.|.|.  .|.:..::...::
plant   520 -KFLELVNNIDRIRHANIVQLVG--FCSEHSQRLLIHEYCRNGTLHDLLHIDDRLKIELSWNVRV 581

  Fly   897 IFAYDTASGMEYLEA---KKVVHRDLAARNVLISEDCVAKVSDFGLA---REECYNLDVGKL--P 953
            ..|.:.|..:|||..   ...:||:..:.|:|:.:|....|||.|||   .....:...|:|  .
plant   582 RIALEAAKALEYLHEICDPPSIHRNFKSANILLDDDIRVHVSDCGLAPLISSGAVSQLSGQLLAA 646

  Fly   954 IKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPR-------------IP-LADV---VK 1001
            ..:.||| .:.|.::.|.|::|||:::.|:.: ||..|.:             || |.|:   .|
plant   647 YGYGAPE-FEYGIYTMKCDVYSFGVVMLELLT-GRKSYDKKRDRGEQFLVRWAIPQLHDIDALAK 709

  Fly  1002 HVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            .|:...|.:.|........:::.:.....|..||..:|:
plant   710 MVDPSLKGDYPAKSLSHFADVISRCVQSEPEYRPLMSEV 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	25/100 (25%)
		PTKc_Csk_like	793..1047	CDD:270635	65/277 (23%)
		STYKc	800..1044	CDD:214568	63/270 (23%)
SRF1	NP_565489.2	LRRNT_2	34..74	CDD:285463
		leucine-rich repeat	102..123	CDD:275380
		leucine-rich repeat	124..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..216	CDD:275380
		leucine-rich repeat	218..241	CDD:275380
		UPF0560	<318..>357	CDD:287538	8/57 (14%)
		PKc_like	484..755	CDD:304357	73/321 (23%)
		Pkinase_Tyr	484..752	CDD:285015	73/321 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I1899
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050