DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and Lyn

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_110484.1	Gene:	Lyn / 81515	RGDID:	621017	Length:	512	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	159/430 - (36%)
Similarity:	235/430 - (54%)	Gaps:	51/430 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   648 WSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAM---PWFHGSITRDEAE-HLLQP-REDGLFL 707
            |.:.|.::.....:....:|          |:|.:   .||...|||.:|| .||.| ...|.||
  Rat   100 WKAKSLSSKREGFIPSNYVA----------KVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 154

  Fly   708 VRESTNFPGDYTLCV-----CFQSKVEHYRVKYLEN-------KLTIDDEEYFENLGQLVAHYEA 760
            :|||....|.::|.|     .....::||:::.|:|       ::|      |..:..::.||:.
  Rat   155 IRESETLKGSFSLSVRDYDPMHGDVIKHYKIRSLDNGGYYISPRIT------FPCISDMIKHYQK 213

  Fly   761 DADGLCTQLIKCLPKLGKQEFCIN---SKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE 822
            .:||||.:|.|.         ||:   .|.:....|.||...::|.:.:|.|:||:|.:|...|.
  Rat   214 QSDGLCRRLEKA---------CISPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNS 269

  Fly   823 -KVAVKMLK-DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSR 885
             |||||.|| ...:.|.||.||::|.||:||.||:...:|...:.:|::||:|:||||:|:|:|.
  Rat   270 TKVAVKTLKPGTMSAQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSD 334

  Fly   886 GRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNL 947
            ....:.....|.|:...|.||.|:|.|..:||||.|.|||:||..:.|::||||||   :..|..
  Rat   335 EGSKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTA 399

  Fly   948 DVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEA 1011
            ..| |.|||||||||:..|.|:.|||:|||||||:||.::|::|||....|||:..:..||:|..
  Rat   400 REGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPR 464

  Fly  1012 PEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNAT 1051
            .|.||.|:|::|:..|..:..:||||..|:..|.....||
  Rat   465 MENCPDELYDIMKMCWKESAEERPTFDYLQSVLDDFYTAT 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	34/113 (30%)
		PTKc_Csk_like	793..1047	CDD:270635	116/259 (45%)
		STYKc	800..1044	CDD:214568	112/249 (45%)
Lyn	NP_110484.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		SH3_Lyn	67..122	CDD:212937	4/31 (13%)
		SH2_Src_Lyn	125..225	CDD:198227	32/105 (30%)
		PTKc_Lyn	239..510	CDD:270657	118/266 (44%)
		Pkinase_Tyr	247..497	CDD:285015	112/249 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820