DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and itk

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_571179.1	Gene:	itk / 798906	ZFINID:	ZDB-GENE-990415-261	Length:	616	Species:	Danio rerio

Alignment Length:	387	Identity:	140/387 - (36%)
Similarity:	224/387 - (57%)	Gaps:	29/387 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 WFHGSITRDEAEHLL-QPREDGLFLVRESTNFPGDYTLCV-----------CFQSKVEHYRVKYL 736
            |::..|.|.|||.|| |..:||.|:||.|.: .|.||:.:           |.|  |:||::|..
Zfish   234 WYNKDINRTEAEDLLMQENKDGGFMVRNSKH-AGVYTVSIFTRVSGSNGEKCPQ--VKHYQIKVQ 295

  Fly   737 ---ENKLTIDDEEY-FENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPE 797
               |..|....|:| |..:.:|:.:::.:..||.|:|..|:.:.......|  |:.....|.|..
Zfish   296 SEGEKVLYYLAEKYLFPTIPELIRYHQHNPAGLITRLRHCVSRNVPNSARI--KELSSDKWEIHP 358

  Fly   798 AELQLRESIGKGEFGDVMLGILRNEKVAVKMLKDEG--AVQKFLAEASVMTTLEHDNLVKFIGLV 860
            .|::|...:|.|:||.|..|..::.:||||.:: ||  :.::|..||.||..|.|:.||:..|:|
Zfish   359 DEVKLSVELGSGQFGLVWKGSWQDREVAVKTVR-EGFMSEEEFKEEAQVMMKLSHNRLVQLYGVV 422

  Fly   861 FTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVL 925
            .....:|||.|:|..|.|.::||:: :..:::|..:....|.:.||.|||:...:||||||||.|
Zfish   423 TQRSPIYLVFEFMENGCLTEFLRAK-KGKLSQKALLEMCLDVSEGMAYLESSNFIHRDLAARNCL 486

  Fly   926 ISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSF 986
            :||:.|.|::|||:.|   ::.|....| |.|::|::||.:|.|::|:|||:||||:.:||:||.
Zfish   487 VSENSVVKIADFGMTRFVLDDQYTSSHGSKFPVRWSSPEVIKFGKYSSKSDVWSFGVFMWEVYSE 551

  Fly   987 GRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLN 1048
            ||.||.....::||:.:..|:::..|..||..:||:|:.:|...|..||:||.|..:|..|:
Zfish   552 GRTPYDNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWSWKEKPEDRPSFALLLHELACLD 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	35/108 (32%)
		PTKc_Csk_like	793..1047	CDD:270635	102/259 (39%)
		STYKc	800..1044	CDD:214568	98/249 (39%)
itk	NP_571179.1	PH	5..110	CDD:278594
		PH_Btk	7..147	CDD:269944
		SH3_Tec_like	170..223	CDD:212702
		SH2_Tec_family	227..338	CDD:198188	35/106 (33%)
		PKc_like	356..610	CDD:304357	100/255 (39%)
		Pkinase_Tyr	361..609	CDD:285015	98/249 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810