Protein Alignment Csk and YES1

DIOPT Version :9

• Sequence 1: NP_001262476.1
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_005424.1
• Gene: YES1 / 7525
• HGNCID: 12841
• Length: 543
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 193/610 - (31%)
• Similarity: 280/610 - (45%)
• Gaps: 110/610 - (18%)

  Fly   472 ISSASNHSPK---SPSQTQQQQQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTA 533
            |.|..|.||.   .|..|.:...|:               :|.:...||  .|.|..|.|..|||
Human     4 IKSKENKSPAIKYRPENTPEPVSTS---------------VSHYGAEPT--TVSPCPSSSAKGTA 51

  Fly   534 AAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLL 598
            .            :...|:..|.||      |......|                    |::...
Human    52 V------------NFSSLSMTPFGG------SSGVTPFG--------------------GASSSF 78

  Fly   599 HTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTA-------GSG---VNASSA--WSSG 651
            ...|    :|.||.:.|       |::..:..:|....|.       |..   :|.:..  |.:.
Human    79 SVVP----SSYPAGLTG-------GVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEAR 132

  Fly   652 STTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEH-LLQP-REDGLFLVRESTNF 714
            |.....:..:....:||..       .:.|..|:.|.:.|.:||. ||.| .:.|:||||||...
Human   133 SIATGKNGYIPSNYVAPAD-------SIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETT 190

  Fly   715 PGDYTLCV-----CFQSKVEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCL 773
            .|.|:|.:     .....|:||:::.|:| ...|.....|:.|.:||.||...|||||.:|....
Human   191 KGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVC 255

  Fly   774 PKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILR-NEKVAVKMLKDEGAV-- 835
            |.:..|     ::......|.||...|:|...:|:|.||:|.:|... ..|||:|.|| .|.:
Human   256 PTVKPQ-----TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLK-PGTMMP 314

  Fly   836 QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAY 900
            :.||.||.:|..|.||.||....:| :.:.:|:|||:||||||:|:|:....:::.....:..|.
Human   315 EAFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAA 378

  Fly   901 DTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEA 961
            ..|.||.|:|....:||||.|.|:|:.|:.|.|::||||||   :..|....| |.|||||||||
Human   379 QIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 443

  Fly   962 LKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQA 1026
            ...|||:.|||:||||||..|:.:.||||||.:...:|::.||.||:|..|:|||..::|:|...
Human   444 ALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508

  Fly  1027 WDLNPAKRPTFAELKVKLQLLNNAT 1051
            |..:|.:||||..::..|:....||
Human   509 WKKDPDERPTFEYIQSFLEDYFTAT 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	38/104 (37%)
		PTKc_Csk_like	793..1047	CDD:270635	113/260 (43%)
		STYKc	800..1044	CDD:214568	109/250 (44%)
YES1	NP_005424.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		13/57 (23%)
		SH3_Yes	94..151	CDD:212940	8/56 (14%)
		SH2_Src_family	154..253	CDD:199827	37/98 (38%)
		PTKc_Yes	264..542	CDD:270654	115/272 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820