DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and TYK2

DIOPT Version :10

Sequence 1:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_001372133.1 Gene:TYK2 / 7297 HGNCID:12440 Length:1257 Species:Homo sapiens


Alignment Length:563 Identity:141/563 - (25%)
Similarity:217/563 - (38%) Gaps:149/563 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   536 VAAVAQQQQQQHLQLLA-NCPPGGAGLMSSSLNAAQMGMHGAE---------RALPPKSLALSGS 590
            :.|::::::.:.:..|| .|.||||..:|::::....|....|         ::..|..:.|   
Human   764 LGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEVCL--- 825

  Fly   591 QHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAG---SGVNAS-----SA 647
              |....|.....||:  .|...:.......:|:.||    .::|:.||   :|...|     |.
Human   826 --GDPWALPAVGAPPR--NPEDRIRAQSCIPSGLVTS----SLSGLPAGGPLAGAQCSPSLFRSL 882

  Fly   648 WSS--GSTTAMNH----ASLSPTALAPQQG--RSRCEVKLNAMPWFHGSITRDEAEHLLQPREDG 704
            |.|  ..|....|    ....|....||..  .|:|                             
Human   883 WKSLVPGTQKKEHFYQRQHRLPEPSCPQLATLTSQC----------------------------- 918

  Fly   705 LFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQL 769
              |..|.|..|...|:                           ..:|.:|..|..||.       
Human   919 --LTYEPTQRPSFRTI---------------------------LRDLTRLQPHNLADV------- 947

  Fly   770 IKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGIL------RNEKVAVKM 828
                       ..:|.........|..:..|:....:|:|.||.|.|...      ..|.||||.
Human   948 -----------LTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKA 1001

  Fly   829 LKDEGAVQK---FLAEASVMTTLEHDNLVKFIGLVFT--SKHLYLVTEYMSKGSLVDYLRSRGRQ 888
            ||.:...|.   :..|..::.||.|::::|:.|....  .|.|.||.||:..|||.|||   .|.
Human  1002 LKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---PRH 1063

  Fly   889 HITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYNL- 947
            .|.....::||.....||.||.|:..:||||||||||:..|.:.|:.|||||:     .|.|.: 
Human  1064 SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVR 1128

  Fly   948 DVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYS---------------FGRVPYPRIPLA 997
            :.|..|:.|.|||.||..:|...||:||||:.|:|:.:               .| :...::.:.
Human  1129 EDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIG-IAQGQMTVL 1192

  Fly   998 DVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            .:.:.:|.|.::..|:.||.|:|.:|:..|:...:.||||..|
Human  1193 RLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 1235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 10/96 (10%)
PTKc_Csk_like 793..1047 CDD:270635 94/280 (34%)
TYK2NP_001372133.1 FERM_F1 28..125 CDD:465733
FERM_F2 143..266 CDD:436450
Jak1_Phl 285..432 CDD:465552
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..366
SH2 437..534 CDD:472789
Protein Kinases, catalytic domain 589..937 CDD:473864 41/241 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..629
PTKc_Tyk2_rpt2 962..1244 CDD:270664 93/278 (33%)
Blue background indicates that the domain is not in the aligned region.

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