DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and TYK2

DIOPT Version :9

Sequence 1:NP_001262476.1 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_001372133.1 Gene:TYK2 / 7297 HGNCID:12440 Length:1257 Species:Homo sapiens


Alignment Length:563 Identity:141/563 - (25%)
Similarity:217/563 - (38%) Gaps:149/563 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   536 VAAVAQQQQQQHLQLLA-NCPPGGAGLMSSSLNAAQMGMHGAE---------RALPPKSLALSGS 590
            :.|::::::.:.:..|| .|.||||..:|::::....|....|         ::..|..:.|   
Human   764 LGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEVCL--- 825

  Fly   591 QHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAG---SGVNAS-----SA 647
              |....|.....||:  .|...:.......:|:.||    .::|:.||   :|...|     |.
Human   826 --GDPWALPAVGAPPR--NPEDRIRAQSCIPSGLVTS----SLSGLPAGGPLAGAQCSPSLFRSL 882

  Fly   648 WSS--GSTTAMNH----ASLSPTALAPQQG--RSRCEVKLNAMPWFHGSITRDEAEHLLQPREDG 704
            |.|  ..|....|    ....|....||..  .|:|                             
Human   883 WKSLVPGTQKKEHFYQRQHRLPEPSCPQLATLTSQC----------------------------- 918

  Fly   705 LFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQL 769
              |..|.|..|...|:                           ..:|.:|..|..||.       
Human   919 --LTYEPTQRPSFRTI---------------------------LRDLTRLQPHNLADV------- 947

  Fly   770 IKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGIL------RNEKVAVKM 828
                       ..:|.........|..:..|:....:|:|.||.|.|...      ..|.||||.
Human   948 -----------LTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKA 1001

  Fly   829 LKDEGAVQK---FLAEASVMTTLEHDNLVKFIGLVFT--SKHLYLVTEYMSKGSLVDYLRSRGRQ 888
            ||.:...|.   :..|..::.||.|::::|:.|....  .|.|.||.||:..|||.|||   .|.
Human  1002 LKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL---PRH 1063

  Fly   889 HITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYNL- 947
            .|.....::||.....||.||.|:..:||||||||||:..|.:.|:.|||||:     .|.|.: 
Human  1064 SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVR 1128

  Fly   948 DVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYS---------------FGRVPYPRIPLA 997
            :.|..|:.|.|||.||..:|...||:||||:.|:|:.:               .| :...::.:.
Human  1129 EDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIG-IAQGQMTVL 1192

  Fly   998 DVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            .:.:.:|.|.::..|:.||.|:|.:|:..|:...:.||||..|
Human  1193 RLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 1235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_001262476.1 SH2_csk_like 680..777 CDD:198190 10/96 (10%)
PTKc_Csk_like 793..1047 CDD:270635 94/280 (34%)
STYKc 800..1044 CDD:214568 93/273 (34%)
TYK2NP_001372133.1 FERM_F1 28..125 CDD:408179
FERM_F2 143..266 CDD:408177
Jak1_Phl 285..432 CDD:407742
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..366
SH2 437..534 CDD:417686
PKc_like 589..937 CDD:419665 41/241 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..629
PTKc_Tyk2_rpt2 962..1244 CDD:270664 93/278 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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