DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and TXK

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_024309968.1	Gene:	TXK / 7294	HGNCID:	12434	Length:	530	Species:	Homo sapiens

Alignment Length:	388	Identity:	142/388 - (36%)
Similarity:	223/388 - (57%)	Gaps:	42/388 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 LNAMPWFHGSITRDEAEHLL-QPREDGLFLVRESTNFPGDYTLCVCF------QSKVEHYRVKYL 736
            |....|:|.:|||::||||| |..::|.|:||:|.:. |.||:.|..      ::.::||::|..
Human   148 LEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIKKN 211

  Fly   737 EN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLI-------KCLPKLGKQEFCINSKDFVDKGW 793
            :: :..:.:...|:::.:|:.:::.:|.||.|:|.       .|||.         :..|..:.|
Human   212 DSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPA---------TAGFSYEKW 267

  Fly   794 VIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLVK 855
            .|..:||...:.||.|:||.|.||..|:. :||:|.: :||::  :.|:.||.||..|.|..||:
Human   268 EIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAI-NEGSMSEEDFIEEAKVMMKLSHSKLVQ 331

  Fly   856 FIGLVFTSKHLYLVTEYMSKGSLVDYLR-SRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDL 919
            ..|:....|.||:|||:|..|.|::||| ::|:  :.|:..:....|...||||||....:||||
Human   332 LYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK--LRKEMLLSVCQDICEGMEYLERNGYIHRDL 394

  Fly   920 AARNVLISEDCVAKVSDFGLAREECYNLD-------VGKLPIKWTAPEALKNGRFSNKSDMWSFG 977
            ||||.|:|..|:.|:||||:.|   |.||       ..|.||||:.||.....::|:|||:||||
Human   395 AARNCLVSSTCIVKISDFGMTR---YVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFG 456

  Fly   978 ILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            :|:||:::.|::|:.......||:.:..|:::..|...|..|||:|...|...|..|||||||
Human   457 VLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAEL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	33/111 (30%)
		PTKc_Csk_like	793..1047	CDD:270635	107/259 (41%)
		STYKc	800..1044	CDD:214568	104/252 (41%)
TXK	XP_024309968.1	SH3_TXK	88..142	CDD:212840
		SH2_Tec_Txk	146..251	CDD:198261	31/103 (30%)
		PTKc_Tec_like	269..524	CDD:173637	106/257 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810