DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and TEC

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_003206.2	Gene:	TEC / 7006	HGNCID:	11719	Length:	631	Species:	Homo sapiens

Alignment Length:	379	Identity:	136/379 - (35%)
Similarity:	215/379 - (56%)	Gaps:	22/379 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 LNAMPWFHGSITRDEAEHLLQPRE-DGLFLVRESTNFPGDYTLCVCFQ------SKVEHYRVKYL 736
            |:...|:..::.|.:||.||:..: :|.|:||:|:. ||.||:.:..:      |...||.:|..
Human   242 LDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFRHYHIKET 305

  Fly   737 ---ENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEA 798
               ..|..:.::..|.::.:::.:::.:|.||.|:|...:...||.  ...:..|..:.|.|..:
Human   306 TTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKN--APTTAGFSYEKWEINPS 368

  Fly   799 ELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLVKFIGLV 860
            ||.....:|.|.||.|.||..|.: |||:|.:: |||:  :.|:.||.||..|.|..||:..|:.
Human   369 ELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR-EGAMCEEDFIEEAKVMMKLTHPKLVQLYGVC 432

  Fly   861 FTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVL 925
            ...|.:|:|||:|.:|.|:::||.| :.|.::...:....|...||||||....:||||||||.|
Human   433 TQQKPIYIVTEFMERGCLLNFLRQR-QGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCL 496

  Fly   926 ISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSF 986
            :||..|.||||||:||   ::.|....| |.|:||..||.....|||:|||:||||:|:||:::.
Human   497 VSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTE 561

  Fly   987 GRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            ||:|:.:....:||..|..|:::..|:.....:||:|.:.|...|..||:|.:|
Human   562 GRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDL 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	26/106 (25%)
		PTKc_Csk_like	793..1047	CDD:270635	106/255 (42%)
		STYKc	800..1044	CDD:214568	103/248 (42%)
TEC	NP_003206.2	PH_Btk	7..148	CDD:269944
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..178
		SH3_Tec	182..237	CDD:212838
		SH2_Tec_Itk	240..346	CDD:198259	27/104 (26%)
		PTKc_Tec_Rlk	365..624	CDD:270685	105/253 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810