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Protein Alignment Csk and SYK

DIOPT Version :10

Sequence 1:	NP_731611.2	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_003168.2	Gene:	SYK / 6850	HGNCID:	11491	Length:	635	Species:	Homo sapiens

Alignment Length:	467	Identity:	154/467 - (32%)
Similarity:	226/467 - (48%)	Gaps:	108/467 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   682 MPWFHGSITRDEAEH--LLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRV-KYLENKLTID 743
            ||||||.|:|:|:|.  |:..:.:|.||:|...| .|.|.||:..:.||.|||: |....||:|.
Human   166 MPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTGKLSIP 229

  Fly   744 DEEYFENLGQLVAHYEADADGLCTQL-IKC----------------------------------- 772
            :.:.|:.|.|||.||...||||...| :.|
Human   230 EGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIK 294

  Fly   773 ---LPKLG----------KQEFCINSKDF--------VDKG----------------WVIPEAEL 800
               .||.|          :||..::...:        .|||                :..|| |:
Human   295 SYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPE-EI 358

  Fly   801 QLRE-------------SIGKGEFGDVMLGILRNEK----VAVKMLKDE----GAVQKFLAEASV 844
            :.:|             .:|.|.||.|..|..:.:|    ||||:||:|    ....:.||||:|
Human   359 RPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANV 423

  Fly   845 MTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYL 909
            |..|::..:|:.|| :..::...||.|....|.|..||:.  .:|:..|:.|...:..:.||:||
Human   424 MQQLDNPYIVRMIG-ICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYL 485

  Fly   910 EAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYNLDV-GKLPIKWTAPEALKNGRFS 968
            |....|||||||||||:.....||:|||||::     |..|.... ||.|:||.|||.:...:||
Human   486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550

  Fly   969 NKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAK 1033
            :|||:||||:|:||.:|:|:.||..:..::|...:|.|.:|..|.|||.|:|::|...|..:...
Human   551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVEN 615

  Fly  1034 RPTFAELKVKLQ 1045
            ||.||.::::|:
Human   616 RPGFAAVELRLR 627

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.