DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and BLK

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_011542126.1	Gene:	BLK / 640	HGNCID:	1057	Length:	531	Species:	Homo sapiens

Alignment Length:	417	Identity:	152/417 - (36%)
Similarity:	225/417 - (53%)	Gaps:	66/417 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 WFHGSITRDEAE-HLLQP-REDGLFLVRESTNFPGDYTLC---VCFQSK-VEHYRVK-------Y 735
            ||..|..|.||| .||.| .:.|.||:|||....|.::|.   |..|.: ::||:::       |
Human   124 WFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYY 188

  Fly   736 LENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCIN---SKDFVDKGWVIPE 797
            :..::|      |.:|..||.||....||||.:|  .||       |:.   ...:....|.||.
Human   189 ISPRIT------FPSLQALVQHYSKKGDGLCQRL--TLP-------CVRPAPQNPWAQDEWEIPR 238

  Fly   798 AELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLVKFIGL 859
            ..|:|...:|.|:||:|.:|..:|. |||:|.|| ||.:  :.||.||:||..|:|:.||:...:
Human   239 QSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLK-EGTMSPEAFLGEANVMKALQHERLVRLYAV 302

  Fly   860 VFTSKHLYLVTEYMSKGS--------------------------LVDYLRSRGRQHITKKDQIIF 898
            | |.:.:|:|||||::|.                          |:|:|::.....::....|..
Human   303 V-TKEPIYIVTEYMARGGAPRRAASSERGGRAGLSRRRRVRCGCLLDFLKTDEGSRLSLPRLIDM 366

  Fly   899 AYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR--EECYNLDVG-KLPIKWTAPE 960
            :...|.||.|:|....:||||.|.|:|:||....|::||||||  :..|....| |.||||||||
Human   367 SAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPE 431

  Fly   961 ALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYE-MMR 1024
            |:..|.|:.|:|:||||:||.|:.::||||||.:...:|::::|.||:|..|:.||||:|. ::.
Human   432 AIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIA 496

  Fly  1025 QAWDLNPAKRPTFAELKVKLQLLNNAT 1051
            :.|...|.:||||..|:..|:....||
Human   497 ECWRSRPEERPTFEFLQSVLEDFYTAT 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	37/105 (35%)
		PTKc_Csk_like	793..1047	CDD:270635	112/286 (39%)
		STYKc	800..1044	CDD:214568	108/276 (39%)
BLK	XP_011542126.1	SH3_Blk	62..115	CDD:212942
		SH2_Src_Blk	120..219	CDD:198234	35/102 (34%)
		PKc_like	233..522	CDD:304357	112/290 (39%)
		Pkinase_Tyr	241..516	CDD:285015	108/276 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820