Protein Alignment Csk and Matk

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_038935769.1
• Gene: Matk / 60450
• RGDID: 69058
• Length: 496
• Species: Rattus norvegicus
• Alignment Length: 426
• Identity: 196/426 - (46%)
• Similarity: 264/426 - (61%)
• Gaps: 42/426 - (9%)

  Fly   655 AMNHAS-----LSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNF 714
            |.:|:|     |:..||..::..| .:.||:.||||||.|:..||...|||.||||||||||...
  Rat    48 AKHHSSGQEGLLAAAALRQREALS-TDPKLSLMPWFHGKISGQEAIQQLQPPEDGLFLVRESARH 111

  Fly   715 PGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQ 779
            ||||.|||.|...|.||||.:.:..||||:...|.||..:|.||..|...:||:|:|...|.|.:
  Rat   112 PGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVCFCNLMDMVEHYTRDKGAICTKLVKPKRKQGAK 176

  Fly   780 EFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVKMLKDEGAVQKFLAEASV 844
            .   ..::....||::....|.|...||:||||.|:.|....:|||||.:|.:...|.||.|.:|
  Rat   177 S---AEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAV 238

  Fly   845 MTTLEHDNLVKFIGLVFTSKH-LYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEY 908
            ||.|:|.|||:.:|::.  .| ||:|.|::|||:||::||:|||..::....:.||...|.||||
  Rat   239 MTKLQHRNLVRLLGVIL--HHGLYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEY 301

  Fly   909 LEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREEC-YNLDVGKLPIKWTAPEALKNGRFSNKSD 972
            ||:||:|||||||||:|:|||.||||||||||:.|. ..||..:||:||||||||||||||:|||
  Rat   302 LESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAELRKGLDSSRLPVKWTAPEALKNGRFSSKSD 366

  Fly   973 MWSFGILLWEIYSFGRVPYPRI-----------------------------PLADVVKHVEVGYK 1008
            :||||:||||::|:||.|||::                             .|.:|.:.||.||:
  Rat   367 VWSFGVLLWEVFSYGRAPYPKMVSSTPGRAACASRVTDCPHPCYPLPPYLQSLKEVSEAVEKGYR 431

  Fly  1009 MEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKL 1044
            ||.|:.||..::.:|...|:..|::||.|.::..||
  Rat   432 MEPPDSCPGPVHTLMGSCWEAEPSRRPPFRKIVEKL 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	51/96 (53%)
		PTKc_Csk_like	793..1047	CDD:270635	134/283 (47%)
Matk	XP_038935769.1	SH3	9..67	CDD:473055	6/18 (33%)
		SH2_csk_like	77..174	CDD:198190	51/96 (53%)
		Protein Kinases, catalytic domain	187..470	CDD:473864	134/283 (47%)