DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and PTK6

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_005966.1	Gene:	PTK6 / 5753	HGNCID:	9617	Length:	451	Species:	Homo sapiens

Alignment Length:	371	Identity:	132/371 - (35%)
Similarity:	202/371 - (54%)	Gaps:	15/371 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   683 PWFHGSITRDEAEHLLQPRED--GLFLVRESTNFPGDYTLCVCFQSKVEHYRV-KYLENKLTIDD 744
            |||.|.|:|.||...||...:  |.||:|.|.....||.|.|.....|.||:: :....:|.:::
Human    77 PWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNE 141

  Fly   745 EEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKG 809
            ...|.:|.:||.::.|.:  |...|....|....:...:...|    .|..|..|..|...:|.|
Human   142 AVSFLSLPELVNYHRAQS--LSHGLRLAAPCRKHEPEPLPHWD----DWERPREEFTLCRKLGSG 200

  Fly   810 EFGDVMLGILRNE-KVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTE 871
            .||:|..|:.::. :||:|::..:..:  |...:|...|..|.|.:::....:|.....:|::||
Human   201 YFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITE 265

  Fly   872 YMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSD 936
            .|:||||::.||....:.:...:.:..|:..|.||.|||::..:||||||||:|:.|:.:.||.|
Human   266 LMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGD 330

  Fly   937 FGLAR---EECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAD 998
            |||||   |:.|......:|.||||||||..|.:|.|||:|||||||.|::|.|:||||.:...:
Human   331 FGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHE 395

  Fly   999 VVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKL 1044
            ....|:.||:|..|..|||.::::|...|..:|.:||.|..|:.:|
Human   396 AFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	31/96 (32%)
		PTKc_Csk_like	793..1047	CDD:270635	100/258 (39%)
		STYKc	800..1044	CDD:214568	96/249 (39%)
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781
		SH2_PTK6_Brk	75..174	CDD:198221	31/98 (32%)
		Linker	171..190		3/22 (14%)
		PTKc_Srm_Brk	184..444	CDD:133248	100/258 (39%)
		STYKc	192..441	CDD:214568	96/248 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820