Protein Alignment Csk and abl2

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_005166946.1
• Gene: abl2 / 570636
• ZFINID: ZDB-GENE-020809-2
• Length: 1182
• Species: Danio rerio
• Alignment Length: 583
• Identity: 197/583 - (33%)
• Similarity: 285/583 - (48%)
• Gaps: 86/583 - (14%)

  Fly   485 QTQQQQQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQ 549
            |||.|    :||||.:..:||.|                 |.:...|.....:.:.
Zfish    17 QTQPQ----SQQQQGRSNRASSS-----------------GRRPRDGGGGGSSTLT--------- 51

  Fly   550 LLANCPPGGAG------LMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNM--LLHTAPQPPQ 606
             |...|||.:.      :....:|...:......|.....|.||:.:...|:.  ||..|...|
Zfish    52 -LTGTPPGRSAAAAVNIMPDPGINVFTLHSEALHRPFGLDSTALTEAVRWSSKENLLGAAESDP- 114

  Fly   607 ASQPAAVVGVSGSGSAGMSTSLHSFDING-----VTAGS-----GVNASSAWSSGSTTAMNHASL 661
                            .:..:|:.|..:|     :|.|.     |.|.:..||  ...:.|....
Zfish   115 ----------------NLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWS--EVRSKNGQGW 161

  Fly   662 SPT-ALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQ 725
            .|: .:.|..       .|....|:||.::|..||:||....:|.||||||.:.||..::.:.::
Zfish   162 VPSNYITPVN-------SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYE 219

  Fly   726 SKVEHYRVKYL-ENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFV 789
            .:|.|||:... :.|:.:..|..|..|.:||.|:...||||.|.|....||..|.  .:.....:
Zfish   220 GRVYHYRINTASDGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKP--TVYGVSPI 282

  Fly   790 DKGWVIPEAELQLRESIGKGEFGDVMLGILR--NEKVAVKMLK-DEGAVQKFLAEASVMTTLEHD 851
            ...|.:...::.::..:|.|::|:|.:|:.:  |..||||.|| |...|::||.|||||..::|.
Zfish   283 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFLKEASVMKEVKHP 347

  Fly   852 NLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVH 916
            |||:.:|:.......|:|||||..|:|:||||...|..:.....:..|...:|.|||||.|..:|
Zfish   348 NLVQLLGVCTLEPPFYIVTEYMPHGNLLDYLRECERDQVNAVVLLYMATQISSAMEYLEKKNFIH 412

  Fly   917 RDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFG 977
            |||||||.|:.|:.|.||:||||:|   .:.|....| |.||||||||:|....||.|||:|:||
Zfish   413 RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 477

  Fly   978 ILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            :|||||.::|..|||.|.|:.|...:|.||:||.||||||::||:||..|..:|..||:|||:
Zfish   478 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWQWSPLDRPSFAEI 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	36/97 (37%)
		PTKc_Csk_like	793..1047	CDD:270635	120/255 (47%)
abl2	XP_005166946.1	SH3_Abl	116..169	CDD:212784	11/54 (20%)
		SH2_ABL	174..267	CDD:198189	34/92 (37%)
		PTKc_Abl	286..548	CDD:270645	120/255 (47%)
		FABD	1057..1182	CDD:197885