DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and btk

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_021336920.1	Gene:	btk / 568653	ZFINID:	ZDB-GENE-070531-1	Length:	640	Species:	Danio rerio

Alignment Length:	382	Identity:	135/382 - (35%)
Similarity:	214/382 - (56%)	Gaps:	29/382 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 LNAMPWFHGSITRDEAEHLLQ-PREDGLFLVRESTNFPGDYTLCVCFQSKVE------HYRVKYL 736
            |....|:..:|.|.:||:||: ..:||.||||:|..|.|.||:.|..::..|      ||.:
Zfish   254 LEKYDWYCKNINRSQAENLLKTENKDGGFLVRDSGKFTGKYTVSVFTKAGGETSGSCRHYNI--- 315

  Fly   737 ENKLTIDDEEY------FENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVI 795
              .||.|.:.|      |.|:.:|:.:::.:|.||.::|...:....:...|.....:  ..|.|
Zfish   316 --LLTADGQFYLAEKHNFTNIPELINYHQHNAAGLVSRLKYIVSNRAQNAPCTAGLGY--GSWEI 376

  Fly   796 PEAELQLRESIGKGEFGDVMLGILR-NEKVAVKMLKDEGAVQK--FLAEASVMTTLEHDNLVKFI 857
            ...:|.....:|.|:||.|..|..: ...||:||:| ||::.:  |:.||.||..|.|.|||:..
Zfish   377 DPRQLTFIRELGNGQFGVVKYGKWQGRHDVAIKMVK-EGSMSEDDFIEEAKVMMKLCHGNLVQLY 440

  Fly   858 GLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAAR 922
            |:....:.:|:||||::.|.|::||: .|..:.|....:....|.:.||:||||.:.:|||||||
Zfish   441 GVCTKQRPIYIVTEYLANGCLLNYLQ-EGLLNPTSIALLEMCKDVSEGMKYLEANQFIHRDLAAR 504

  Fly   923 NVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEI 983
            |.|:..:...||:||||:|   ::.|...|| |.|::|:.||.|...:||:|||:|:||:|:|||
Zfish   505 NCLVDSNGTIKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKSDIWAFGVLMWEI 569

  Fly   984 YSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            |:.||:||.|....::|:.:..|:::..|:.....::.:|...|...|.:||||.||
Zfish   570 YTQGRMPYDRWNNTEIVEKISAGHRLYRPQMANENVFAIMNSCWHERPDERPTFQEL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	33/109 (30%)
		PTKc_Csk_like	793..1047	CDD:270635	100/255 (39%)
		STYKc	800..1044	CDD:214568	98/248 (40%)
btk	XP_021336920.1	PH_Btk	6..145	CDD:269944
		SH3	195..249	CDD:327375
		SH2	252..357	CDD:326550	34/107 (32%)
		PKc_like	376..630	CDD:328722	99/253 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910