DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and blk

DIOPT Version :10

Sequence 1:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:XP_017208000.1 Gene:blk / 567764 ZFINID:ZDB-GENE-040724-106 Length:501 Species:Danio rerio


Alignment Length:372 Identity:148/372 - (39%)
Similarity:216/372 - (58%) Gaps:22/372 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   684 WFHGSITRDEAEHLL--QPREDGLFLVRESTNFPGDYTLCVCFQSK-----VEHYRVKYLEN-KL 740
            ||...:.|.:.|.||  ...:.|.||||||....|.::|.:...:.     |:||:::.|:| ..
Zfish   120 WFFKDMNRRDTERLLLAPGNKPGSFLVRESETTKGAFSLSIRDSTPEQGDVVKHYKIRALDNGGY 184

  Fly   741 TIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRES 805
            .|.....|.:|.:||.:|...|||||.:|.........|      :.:....|.||...|:|.:.
Zfish   185 YISPSTSFSSLQELVKYYSRTADGLCQRLGNPCKSTAPQ------RPWAQDEWEIPRETLKLVKK 243

  Fly   806 IGKGEFGDVMLGILR-NEKVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLY 867
            :|.|:||:|.:|..: |:|||:|.|| ||.:  :.||.||::|..|:|:.||| :..|.|.:.:|
Zfish   244 LGAGQFGEVWMGFYKNNQKVAIKTLK-EGTMEPEAFLQEANLMKQLQHERLVK-LHAVVTREPIY 306

  Fly   868 LVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVA 932
            :|||||:.|||:|:|::.....:.....|......|.||.|:|.|..:||||.|.|:|:||....
Zfish   307 IVTEYMANGSLLDFLKTDDGHKLKLSKLIDMTAQIAEGMAYIERKNYIHRDLRAANILVSETLHC 371

  Fly   933 KVSDFGLAR--EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRI 994
            |::||||||  |..|....| |.|||||||||:..|.|:.|||:|||||||.||.::||||||.:
Zfish   372 KIADFGLARIIETEYTAQEGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTYGRVPYPGM 436

  Fly   995 PLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELK 1041
            ...:|:::::..|:|..|:.||.|:|::|.:.|...|..||||..|:
Zfish   437 TNPEVIRNLDRNYRMPCPDACPGELYDIMTKCWMEKPEDRPTFEYLQ 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 32/100 (32%)
PTKc_Csk_like 793..1047 CDD:270635 115/255 (45%)
blkXP_017208000.1 SH3_Blk 58..111 CDD:212942
SH2_Src_family 116..216 CDD:199827 32/95 (34%)
PTKc_Lck_Blk 230..492 CDD:270652 115/256 (45%)
Blue background indicates that the domain is not in the aligned region.

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