DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and jak3

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_002663133.4	Gene:	jak3 / 561370	ZFINID:	ZDB-GENE-070725-4	Length:	1103	Species:	Danio rerio

Alignment Length:	1033	Identity:	227/1033 - (21%)
Similarity:	388/1033 - (37%)	Gaps:	298/1033 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 TTTTTSATSAKHESSPPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLG-----NSRERTSKN 248
            ||:..|.....|..    |.:.:|.|           |:.::::|..|||.     ::.||:.|.
Zfish   188 TTSYKSCLPETHRQ----DIQRMNRL-----------ARYQIRKTLKRFLKKLGKCSAGERSLKL 237

  Fly   249 GQQTSRS-LPPIASSEE-------WFDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRKASGEG 305
            ......| |.|...||.       |.::..|.|                      .::.|.||||
Zfish   238 KYLMKLSELEPDYGSESFPLHHSGWLEQSEQQR----------------------VLAVKVSGEG 280

  Fly   306 -------------------DLITVEIKQGLLRKQ--------TATTTTGQAMNSH---ATATQNG 340
                               .:|.:.||: |.::|        |.|....|.|.:.   .|...:.
Zfish   281 GIQIQKTDRQEWQTFCDFPQIIDISIKR-LCQEQMPLEGRVVTLTRQDDQCMEAEFQTLTDALSF 344

  Fly   341 QTTVVGHHRGFSQPSVTVAAAAATGSTAGD-------PWFLQTTGHQMPPTAP------LRHNKR 392
            .:.|.|:.|..:..:....|..|..|...|       |...:...|::.....      |||:.:
Zfish   345 VSLVDGYFRLTTDSTHYFCAEVAPPSLLEDIQNYCHGPITSEFAVHKLKKAGGKNGMFLLRHSPK 409

  Fly   393 PAPQ---------------PNAVLGAGSSGTAPGSAVGAVLLHQ----QQLSQSQPHIVPPSI-- 436
            ...:               .:.::......:..|.....:.|.|    .|||......:|.::
Zfish   410 EFDKYFLTVCIQTPLGMDYKDCLIEKNEKFSLAGIHNSFINLKQLIDFYQLSTLYVSDIPVTLGK 474

  Fly   437 --PPHHHH------HRENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTT 493
              ||....      .|.:::..|.:......|..|| :..|.:     .|.....|::..|...|
Zfish   475 CCPPRAKELTNMIIIRNSSMTEIPSSPTLQRHKPSH-MQFHMI-----KHEDLIWSESLGQGSFT 533

  Fly   494 N---QQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCP 555
            :   ..:..|:...:||       ...:..|..|..::...:....|::..|...:||.|:.
Zfish   534 HIFRGSKIDQRDGGTHS-------TEVLLKVLDANHKNCWESLFEAASLMSQISHRHLLLVY--- 588

  Fly   556 PGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGS---------------------QHGS----N 595
             |.:...|.::...:...|||......:|:.:|.|                     .||:    |
Zfish   589 -GISVHKSKNIMVQEFVKHGALDLYLKRSMCVSVSWKLDVAKQLACALNFLEEKNIAHGNICAKN 652

  Fly   596 MLLHTAPQPP--QASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNH 658
            :||......|  :.|.|            |:|.||...|:        |.....|
Zfish   653 LLLVREGDSPFIKLSDP------------GVSMSLLGKDV--------VLDRIPW---------- 687

  Fly   659 ASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRD---EAEHLLQPREDGLFLVRESTNFPGDYTL 720
              ::|..|      ...|::|....|..|:...:   ..|..||    ||.|::
Zfish   688 --VAPEVL------DTLEIELECDKWSFGTTLWEIFNGGEAPLQ----GLDLMQ----------- 729

  Fly   721 CVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAH---YEADADGLCTQLIKCLPKLGKQEF- 781
                       ::::.||...:...|:.| |.:|::|   |:.:....|..:|:.|..|...::
Zfish   730 -----------KLQFYENFSNLPTLEWTE-LAELISHCMQYQPELRPSCRSIIRQLNSLITSDYE 782

  Fly   782 CINSKDFVDKG---W------------VIPEAELQLRESIGKGEFGDVML------GILRNEKVA 825
            .:::.|.:.:.   |            |..|..|:....:|||.||.|.|      |....|.||
Zfish   783 ILHATDTLPESNGFWKKLNIFKKQQEDVFEERYLRFISVLGKGNFGSVELCRYDPWGDNTGELVA 847

  Fly   826 VKMLKD--EGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHL--YLVTEYMSKGSLVDYLRSRG 886
            ||.|:.  :..:..|..|...:::|..|.:||:.|:.:::..|  .||.||:..|||:.|: .:.
Zfish   848 VKELQSNKQATMADFQREIQTISSLHCDYIVKYKGICYSTGRLSTKLVMEYLPYGSLIGYM-EKH 911

  Fly   887 RQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYN 946
            |.::..:..::||.....|||||::.:.|||||||||:|::.|.:.|::||||.:     :|.|.
Zfish   912 RHNVGNRKLLLFASQICKGMEYLQSMRYVHRDLAARNILVASDNLVKIADFGLTKIIPVDKEYYR 976

  Fly   947 L-DVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSF---------------GRV---PYP 992
            : ..|:.|:.|.|||::...:||:|||:|||||:|.|::|:               ||.   |..
Zfish   977 VTQPGESPVFWYAPESISELKFSHKSDVWSFGIVLHELFSYCDISQNPKKLCIQKIGRYVHSPSM 1041

  Fly   993 RIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNA 1050
            .|.|..::|:   .:::.||..||.:::.:|.|.|:.|...||:|:.||   .|:.|:
Zfish  1042 AIHLLTLLKN---NWRLPAPAQCPLKVHSIMMQCWEFNSENRPSFSSLK---DLIENS 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	19/102 (19%)
		PTKc_Csk_like	793..1047	CDD:270635	98/299 (33%)
		STYKc	800..1044	CDD:214568	95/277 (34%)
jak3	XP_002663133.4	B41	26..255	CDD:214604	20/81 (25%)
		FERM_C_JAK3	251..365	CDD:275413	23/136 (17%)
		SH2_Jak3	365..459	CDD:198243	11/93 (12%)
		PKc_like	521..774	CDD:304357	58/328 (18%)
		Pkinase_Tyr	521..773	CDD:285015	58/327 (18%)
		PTKc_Jak_rpt2	811..1091	CDD:270634	97/286 (34%)
		TyrKc	816..1090	CDD:197581	95/280 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910