DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and ptk6a

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_682778.6	Gene:	ptk6a / 555232	ZFINID:	ZDB-GENE-081105-117	Length:	563	Species:	Danio rerio

Alignment Length:	564	Identity:	178/564 - (31%)
Similarity:	260/564 - (46%)	Gaps:	98/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   573 MHGAERALPPKSLALSGSQHGSNML----LHTAPQPPQASQPAAVVGVSGSGS------------ 621
            ||......|..||:||.|...|..|    ||......:.::|||.|..|.|..
Zfish     1 MHNLSVLHPALSLSLSLSLSLSLSLSFRNLHVKYHSSRPAKPAAKVIDSHSDEMSQEEVCCSCPG 65

  Fly   622 -----AGMSTSLHSFDINGV--TAGSGVNA-----SSAWSSGS---TTAMNHASLSPTALAPQQG 671
                 .|:.||....:....  ||...||.     :||...||   ....::.:.....|:.|:|
Zfish    66 LRAFCQGLFTSPDKTEAEKPTNTAKQTVNVPNPSRASACEPGSELYKALWSYKARGADELSFQEG 130

  Fly   672 RS--RCE--------VKL-----------------------NAMPWFHGSITRDEAE-HLLQPRE 702
            ..  .||        :||                       ...||:.|::.|.|.| .||.|..
Zfish   131 EQFRICERQGEWWTALKLGRDGAVTGRGFVPNHFLARRQTVKEQPWYFGTLNRFETEILLLAPEN 195

  Fly   703 D-GLFLVRESTNFPGDYTLCVCF---QSKVEHYRVKYLENK-LTIDDEEYFENLGQLVAH---YE 759
            | |.||||.|......|.|.|..   ..:|:|.::...:|: ..:|..:.|::|.:||.:   |.
Zfish   196 DVGAFLVRHSEKDNIGYVLSVLSGDRSREVKHIKIHQNQNESFYLDKSQTFQSLEKLVDYYWKYS 260

  Fly   760 ADADGLCTQLIKCL---PKLGKQEFCINSKDF---VDKGWVIPEAELQLRESIGKGEFGDVMLGI 818
            .|.|....|  .|.   ||         .||.   ....|.:|:.|..|.|.:|||.|.||..|.
Zfish   261 LDGDSFLKQ--PCRRPEPK---------PKDLSHSTVNDWELPKEEFTLEEELGKGFFADVYRGK 314

  Fly   819 LRN-EKVAVKMLKDEGA-VQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDY 881
            .:. ..||:|:||::.. .::|:.|..::..|.|.:|:....:..:|...|::||.|.||.|:..
Zfish   315 WKGMVNVAIKILKNDSINHREFMLETQILKKLRHKHLIALFAVCTSSSPFYIITELMEKGDLLSL 379

  Fly   882 LRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EE 943
            |:.:..|.:..:.....|...|.||.|||.:..:||||||||||:..:.:.||:|.||||   |.
Zfish   380 LKGKEGQDLNAQMLTEMASQVADGMAYLEEQNSIHRDLAARNVLVGANYICKVADLGLARIVKES 444

  Fly   944 CYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYK 1008
            .|:.:..::|.||:||||:.:||||||||:||||:||:|::::|.||||.....:|...:..||:
Zfish   445 VYSSEDAQIPYKWSAPEAISHGRFSNKSDVWSFGVLLYEMFTYGGVPYPAFSNIEVYNMITSGYR 509

  Fly  1009 MEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNATA 1052
            |.||..||..||::|...|..:..:||.|:||   |:||.:..|
Zfish   510 MPAPPNCPSHIYDIMLMCWRYSAEERPDFSEL---LRLLEDYCA 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	34/108 (31%)
		PTKc_Csk_like	793..1047	CDD:270635	103/258 (40%)
		STYKc	800..1044	CDD:214568	99/248 (40%)
ptk6a	XP_682778.6	SH3_Brk	110..167	CDD:212781	7/56 (13%)
		SH2	174..261	CDD:214585	28/86 (33%)
		PKc_like	289..541	CDD:328722	100/251 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820