Protein Alignment Csk and MAP3K20

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_057737.2
• Gene: MAP3K20 / 51776
• HGNCID: 17797
• Length: 800
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 90/265 - (33%)
• Similarity: 145/265 - (54%)
• Gaps: 22/265 - (8%)

  Fly   799 ELQLRESIGKGEFGDVMLG--ILRNEKVAVKMLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVF 861
            :||..|:.|.|.||.|...  |.::::||||.|      .|...||.:::.|.|.|:::|.|::.
Human    15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL------LKIEKEAEILSVLSHRNIIQFYGVIL 73

  Fly   862 TSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAK---KVVHRDLAARN 923
            ...:..:||||.|.|||.||:.|...:.:.....:.:|.|.|.||.||..:   ||:||||.:||
Human    74 EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRN 138

  Fly   924 VLISEDCVAKVSDFGLAREECYNLD---VGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYS 985
            |:|:.|.|.|:.|||.:|...:...   ||..|  |.|||.:::...|...|.:|:|::|||:.:
Human   139 VVIAADGVLKICDFGASRFHNHTTHMSLVGTFP--WMAPEVIQSLPVSETCDTYSYGVVLWEMLT 201

  Fly   986 FGRVPY---PRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLL 1047
             ..||:   ..:.:|.:|  ||...::..|..||....|::.|.|:.:..|||:|.::...|:.:
Human   202 -REVPFKGLEGLQVAWLV--VEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263

  Fly  1048 NNATA 1052
            :|.|:
Human   264 SNDTS 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190
		PTKc_Csk_like	793..1047	CDD:270635	88/258 (34%)
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	85/251 (34%)
		Leucine-zipper	287..308
		SAM_MLTK	338..408	CDD:188928
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	652..800
		Sensing domain (S). /evidence=ECO:0000269|PubMed:32289254	670..713
		C-terminal domain (CTD). /evidence=ECO:0000269|PubMed:32289254	774..800