DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Csk and Ptk2b

DIOPT Version :10

Sequence 1:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_059014.2 Gene:Ptk2b / 50646 RGDID:628758 Length:1009 Species:Rattus norvegicus


Alignment Length:331 Identity:112/331 - (33%)
Similarity:171/331 - (51%) Gaps:43/331 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   749 ENLGQLVAHYEADADGLCTQLIKCLPKLGKQ-------EFCINSKDFVDKGWVIPEAELQ----- 801
            |:.|.|:.|  |..||.....:..:|.|..:       |.|....|...:   ||:..|:     
  Rat   357 EHKGSLIIH--AKKDGEKRNSLPQIPTLNLESRRSHLSESCSIESDIYAE---IPDETLRRPGGP 416

  Fly   802 ----------LRESIGKGEFGDVMLGILRNEK-----VAVKMLKDEGAV---QKFLAEASVMTTL 848
                      |...:|:|.||:|..|:..|.|     ||||..|.:..:   :||::||.:|..|
  Rat   417 QYGVAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 481

  Fly   849 EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKK 913
            :|.::||.||:: ..:..::|.|....|.|..|| .|.:..:.....:::|......|.|||:..
  Rat   482 DHPHIVKLIGII-EEEPTWIVMELYPYGELGHYL-ERNKNSLKVPTLVLYALQICKAMAYLESIN 544

  Fly   914 VVHRDLAARNVLI-SEDCVAKVSDFGLAR----EECYNLDVGKLPIKWTAPEALKNGRFSNKSDM 973
            .||||:|.||:|: |.:|| |:.||||:|    |:.|...|.:|||||.:||::...||:..||:
  Rat   545 CVHRDIAVRNILVASPECV-KLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDV 608

  Fly   974 WSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFA 1038
            |.|.:.:|||.|||:.|:..:...||:..:|.|.::..||.|||.:|.:|.:.||.:|:.||.|.
  Rat   609 WMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFT 673

  Fly  1039 ELKVKL 1044
            ||...|
  Rat   674 ELVCSL 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 8/27 (30%)
PTKc_Csk_like 793..1047 CDD:270635 100/280 (36%)
Ptk2bNP_059014.2 FERM_N_2 39..137 CDD:436229
B41 41..254 CDD:214604
FERM_C_FAK1 261..368 CDD:270011 5/12 (42%)
PTKc_FAK 418..687 CDD:133187 97/265 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 702..725
Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:9422762 801..1009
Focal adhesion targeting (FAT) 868..1009
Focal_AT 872..1001 CDD:460992
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.