Protein Alignment Csk and ptk2b

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_012819490.1
• Gene: ptk2b / 496459
• XenbaseID: XB-GENE-489525
• Length: 1017
• Species: Xenopus tropicalis
• Alignment Length: 470
• Identity: 137/470 - (29%)
• Similarity: 207/470 - (44%)
• Gaps: 116/470 - (24%)

  Fly   653 TTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGD 717
            |..||..|   |..:..|...|||:   |..|   |||.|   .::.|:.     :|:.|.....
 Frog   244 TRFMNTLS---TFTSIDQETYRCEL---AQGW---SITVD---LVIGPKG-----IRQLTTKDSK 291

  Fly   718 YTLCVCFQSKVEHYRVKYLENKLTIDDEEYF---------------------ENLGQLVAHYEAD 761
            .|   ||   .|..::|.::..|..|.....                     ||:..|:
 Frog   292 PT---CF---AEFKQIKSIKCSLLEDGWALLLLGISGAPQPLAIKTSSLAVAENMADLI------ 344

  Fly   762 ADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPE---AELQLRES------------------ 805
             ||.|.     |....|....:|.|...:|...:|:   .|:|:|.|
 Frog   345 -DGYCR-----LQNESKDSLIVNPKKDNEKRISLPQIPTEEVQVRRSRLVEGNSMESDIYAEIPE 403

  Fly   806 -----------------------IGKGEFGDVMLGILRNEK-----VAVKMLKDEGAV---QKFL 839
                                   :|:|.||:|..|:....|     ||||..|::.|.   :||:
 Frog   404 VTETKLTNNRFTISRSDVALGRILGEGFFGEVYDGVYVKPKGDKINVAVKTCKNDCAADVKEKFM 468

  Fly   840 AEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTAS 904
            :||.:|..|:|.::||.||:: ....:::|.|....|.|..|| .:.:..:.....|:::.....
 Frog   469 SEAYLMRNLDHPHIVKLIGII-EDDPIWIVMELYPYGELGQYL-EKNKNSLQVLSLILYSLQICK 531

  Fly   905 GMEYLEAKKVVHRDLAARNVLI-SEDCVAKVSDFGLAR----EECYNLDVGKLPIKWTAPEALKN 964
            .:.|||....||||:|.||:|: |.:|| |:.||||:|    ||.|...|.:|||||.|||::..
 Frog   532 ALAYLEGINCVHRDIAVRNILVASPECV-KLGDFGLSRYLEEEEYYKASVTRLPIKWMAPESINF 595

  Fly   965 GRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDL 1029
            .||::.||:|.||:.:|||.|||:.|:..:...||:..:|.|.::..||.|||.:|.:|.:.|..
 Frog   596 RRFTSASDVWMFGVCMWEILSFGKQPFFWLENKDVISVIEKGDRLPKPEMCPPTLYTLMTRCWTY 660

  Fly  1030 NPAKRPTFAELKVKL 1044
            :|.:||.|.||...|
 Frog   661 DPFERPKFTELVCSL 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	23/117 (20%)
		PTKc_Csk_like	793..1047	CDD:270635	101/309 (33%)
ptk2b	XP_012819490.1	FERM_N_2	35..133	CDD:436229
		B41	37..261	CDD:214604	6/19 (32%)
		FERM_C_FAK1	257..364	CDD:270011	29/138 (21%)
		PTKc_FAK	414..683	CDD:133187	96/265 (36%)
		Focal_AT	880..1009	CDD:460992