Protein Alignment Csk and yes1

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001008186.1
• Gene: yes1 / 493548
• XenbaseID: XB-GENE-495082
• Length: 537
• Species: Xenopus tropicalis
• Alignment Length: 526
• Identity: 182/526 - (34%)
• Similarity: 263/526 - (50%)
• Gaps: 84/526 - (15%)

  Fly   588 SGSQHGSNMLLHTAPQPPQASQPAAVVGVSGS----------GSAGMSTSLHSFDI--------- 633
            ||||:|.:        |.||:|...:.|.:.:          ||:|::....:..|
 Frog    24 SGSQYGGD--------PTQATQSPGIKGPAPNFNSHSMTPFGGSSGITPFGGASSIFSPTPVPYP 80

  Fly   634 NGVTAGSGV---------------------------NASSAWSSGSTTAMNHASLSPT-ALAPQQ 670
            .|:|.|..|                           |....|....:.|.......|: .:||..
 Frog    81 GGLTGGVTVFVALYDYEARTTEDLSFRKGERFQIINNTEGDWWEARSIATGKTGYIPSNYVAPAD 145

  Fly   671 GRSRCEVKLNAMPWFHGSITRDEAEH-LLQP-REDGLFLVRESTNFPGDYTLCV-----CFQSKV 728
                   .:.|..|:.|.:.|.:||. ||.| .:.|.||||||....|.|:|.:     .....|
 Frog   146 -------SIQAEEWYFGKMGRKDAERLLLNPGNQRGTFLVRESETTKGAYSLSIRDWDEVRGDNV 203

  Fly   729 EHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKG 792
            :||:::.|:| ...|.....||:|.:||.||...|||||.:|....|.:..|...: |||    .
 Frog   204 KHYKIRKLDNGGYYITTRAQFESLQKLVKHYSEHADGLCYRLTTVCPTVKPQTQGL-SKD----A 263

  Fly   793 WVIPEAELQLRESIGKGEFGDVMLGILR-NEKVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLV 854
            |.||...|:|...:|:|.||:|.:|... ..|||:|.|| .|.:  :.||.||.:|..|.||.||
 Frog   264 WEIPRESLRLDVKLGQGCFGEVWIGTWNGTTKVAIKTLK-PGTMMPEAFLQEAQIMKKLRHDKLV 327

  Fly   855 KFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDL 919
            ....:| :.:.:|:|||||:||||:|:|:....:::.....:..|...|.||.|:|....:||||
 Frog   328 PLYAVV-SEEPIYIVTEYMTKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDL 391

  Fly   920 AARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILL 980
            .|.|:|:.::.|.|::||||||   :..|....| |.|||||||||...|||:.|||:|||||||
 Frog   392 RAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILL 456

  Fly   981 WEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQ 1045
            .|:.:.||||||.:...:|::.||.||:|..|:|||..::|:|:..|..:|.:||||..::..|:
 Frog   457 TELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMKLCWKKDPDERPTFEYIQSFLE 521

  Fly  1046 LLNNAT 1051
            ....||
 Frog   522 DYFTAT 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	39/104 (38%)
		PTKc_Csk_like	793..1047	CDD:270635	113/260 (43%)
yes1	NP_001008186.1	SH3_Yes	88..145	CDD:212940	7/56 (13%)
		SH2_Src_family	148..247	CDD:199827	38/98 (39%)
		PTKc_Yes	258..536	CDD:270654	118/277 (43%)