Protein Alignment Csk and MST1R

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_005265227.2
• Gene: MST1R / 4486
• HGNCID: 7381
• Length: 1401
• Species: Homo sapiens
• Alignment Length: 1186
• Identity: 283/1186 - (23%)
• Similarity: 415/1186 - (34%)
• Gaps: 385/1186 - (32%)

  Fly    13 FIQSNSYLMPTPSPSGADA------------TVSSSLERVLKPASASASPSNSNNESDNSQTSSG 65
            |.||.|:   .|:|.|.:|            .||||..||               :..|......
Human   400 FFQSPSF---CPNPPGLEALSPNTSCRHFPLLVSSSFSRV---------------DLFNGLLGPV 446

  Fly    66 SQTASSASKRSNRSVGRSHRGSIAQDTRRRYYFGSKDIYWCKQSREAAAAATLSGSGLTRSASSV 130
            ..||...::..|.:|  :|.|::  |.|         |...:..|.......:|...|..|...|
Human   447 QVTALYVTRLDNVTV--AHMGTM--DGR---------ILQVELVRSLNYLLYVSNFSLGDSGQPV 498

  Fly   131 THKEASTHATH----TGGQVISRARRKP----ILLCSSLSAAYAPPRRREFYFC---------DK 178
             .::.|....|    :|.||.....:.|    .|.|.....|:      .|..|         .|
Human   499 -QRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAW------HFMGCGWCGNMCGQQK 556

  Fly   179 YAPGPARSTPTTTTTSATSAKHESSPPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFL----G 239
            ..||              |.:.:..||   :|..|    |......:..|.|......|.    |
Human   557 ECPG--------------SWQQDHCPP---KLTEF----HPHSGPLRGSTRLTLCGSNFYLHPSG 600

  Fly   240 NSRERTSK--NGQQTSRSLPPIASSEEWFDEEAQARKTSHEKSQKPKPKP-----EENHKEKEAI 297
            ...|.|.:  .||...|.||                    :.|.|.:|.|     ||...|.|.:
Human   601 LVPEGTHQVTVGQSPCRPLP--------------------KDSSKLRPVPRKDFVEEFECELEPL 645

  Fly   298 SRKASGEGDLITVEIKQGLLRKQTATTTTGQAMNSHATATQNGQTTVVGHHRGFS--QPSVTVAA 360
            ..:|.|..::              :.|.|......|...  :| |:|:   ||||  :| |.:|.
Human   646 GTQAVGPTNV--------------SLTVTNMPPGKHFRV--DG-TSVL---RGFSFMEP-VLIAV 689

  Fly   361 AAATGSTAGDPWFLQTTGHQMPPTAPLRHNKRPAPQPNAVLGAGSS-------------GTAPGS 412
            ....|..||.. .|...|..:           ......|||..|:.             .|.||:
Human   690 QPLFGPRAGGT-CLTLEGQSL-----------SVGTSRAVLVNGTECLLARVSEGQLLCATPPGA 742

  Fly   413 AVGAVLLHQQQLSQSQPHIVPPSIPPHHHHHRENNVHPIQAGAAAALHLSSHA--LNSHNLI--- 472
            .|.:|.| ..|:..:|   ||.|   ....:||:.|         .|.:|.:.  :|||..|
Human   743 TVASVPL-SLQVGGAQ---VPGS---WTFQYREDPV---------VLSISPNCGYINSHITICGQ 791

  Fly   473 --SSA-----SNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQP----AGS 526
              :||     |.|......:::|.::...:||              ....|......|    ||:
Human   792 HLTSAWHLVLSFHDGLRAVESRQCERQLPEQQ--------------LCRLPEYVVRDPQGWVAGN 842

  Fly   527 QSVAGTAAA----------------VAAVAQQQQQQH--------LQLLANC------------- 554
            .|..|..||                .|.:...:.::|        |..:|:|
Human   843 LSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQ 907

  Fly   555 ------------PPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQA 607
                        ||           :.|:|..||     |..:.:.|..|....::...|.
Human   908 HEFRGDMVVCPLPP-----------SLQLGQDGA-----PLQVCVDGECHILGRVVRPGPD---- 952

  Fly   608 SQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAM-----NHASLSPTALA 667
                   ||..|...|:...|    :..|.|.:.....|.|.......:     :.|||..||.|
Human   953 -------GVPQSTLLGILLPL----LLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGA 1006

  Fly   668 PQQGRSRCEVKLNAMP-WFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHY 731
                        ..:| .:.||   |....|..|..|||           |.|.||        :
Human  1007 ------------TPLPILYSGS---DYRSGLALPAIDGL-----------DSTTCV--------H 1037

  Fly   732 RVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFV----DKG 792
            ...:.::    :||                         .|:|.|.|:...:...|..    .|.
Human  1038 GASFSDS----EDE-------------------------SCVPLLRKESIQLRDLDSALLAEVKD 1073

  Fly   793 WVIPEAELQLRES--IGKGEFGDVMLGILRNE-----KVAVKMLK---DEGAVQKFLAEASVMTT 847
            .:||...:.....  ||||.||.|..|...::     :.|:|.|.   :...|:.||.|..:|..
Human  1074 VLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRG 1138

  Fly   848 LEHDNLVKFIGLVFTSKHL-YLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEA 911
            |.|.|::..||::...:.| :::..||..|.|:.::||..| :.|.||.|.|....|.|||||..
Human  1139 LNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQR-NPTVKDLISFGLQVARGMEYLAE 1202

  Fly   912 KKVVHRDLAARNVLISEDCVAKVSDFGLARE----ECYNLDV---GKLPIKWTAPEALKNGRFSN 969
            :|.|||||||||.::.|....||:||||||:    |.|::..   .:||:||.|.|:|:..||:.
Human  1203 QKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTT 1267

  Fly   970 KSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKR 1034
            |||:||||:||||:.:.|..||..|...|:...:..|.::..||.||..:|::|:|.|:.:||.|
Human  1268 KSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVR 1332

  Fly  1035 PTFAELKVKLQLLNNA 1050
            |||..|..:::.:.:|
Human  1333 PTFRVLVGEVEQIVSA 1348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	17/97 (18%)
		PTKc_Csk_like	793..1047	CDD:270635	104/271 (38%)
MST1R	XP_005265227.2	Sema_RON	27..523	CDD:200540	34/154 (22%)
		PSI	526..568	CDD:396154	9/61 (15%)
		IPT_plexin_repeat1	569..683	CDD:238585	35/160 (22%)
		IPT_plexin_repeat2	684..768	CDD:238584	23/103 (22%)
		IPT	769..860	CDD:214657	22/113 (19%)
		PTKc_Met_Ron	1087..1348	CDD:270649	102/261 (39%)