DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and lyn

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001004543.1	Gene:	lyn / 447804	ZFINID:	ZDB-GENE-040912-7	Length:	510	Species:	Danio rerio

Alignment Length:	488	Identity:	171/488 - (35%)
Similarity:	257/488 - (52%)	Gaps:	58/488 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   600 TAPQPPQASQPAAVVGVSGSGSAGMS------------TSLHSFDINGVTAGSGVNA----SSAW 648
            |:.:||..||.|.:  :.|.....|.            .::|:.|: |...|..:..    ...|
Zfish    37 TSYKPPITSQNAGL--LPGQVFQKMEEKEKIVVALYPYEAIHADDL-GFKKGEKLKIIEEHGEWW 98

  Fly   649 SSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAE-HLLQP-REDGLFLVRES 711
            .:.|.|......:....:|...       .:....||:..|||.:|| .||.| .:.|.:|:|||
Zfish    99 KARSLTTRKEGFIPSNYVAEAD-------TMETEEWFYKDITRKDAERQLLAPANKPGSYLIRES 156

  Fly   712 TNFPGDYTLCV-----CFQSKVEHYRVKYLEN-------KLTIDDEEYFENLGQLVAHYEADADG 764
            ....|.|:|.:     ..|..|:||:::.|:|       |:|      |.::..::.||...:||
Zfish   157 ETSKGSYSLSIRDVDAQGQDVVKHYKIRSLDNGGYYISPKIT------FSDISSMIKHYHKQSDG 215

  Fly   765 LCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKM 828
            ||.:|.|...|...|      |.:....|.|.:..:::.:.:|.|:||:|.:....|. |||||.
Zfish   216 LCRKLDKACEKPKAQ------KPWDKDAWEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVAVKT 274

  Fly   829 LK-DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITK 892
            || ...:|:.||.||::|.||:||.||:...:|..::.:|::||||:.|||:|:|:|:....|..
Zfish   275 LKPGTMSVEAFLEEANLMKTLQHDRLVRLYAVVTKTEPIYIITEYMANGSLLDFLKSQAGSKIQL 339

  Fly   893 KDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLP 953
            ...|.|:...|.||.|:|.|..:||||.|.|||:||..:.|::||||||   ::.|....| |.|
Zfish   340 PKLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSEMLLCKIADFGLARVIEDDQYTAREGAKFP 404

  Fly   954 IKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPE 1018
            ||||||||:..|.|:.||||||||:||:||.::|::|||.:..::|:..|:.||:|..||.||.|
Zfish   405 IKWTAPEAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYRMPRPENCPVE 469

  Fly  1019 IYEMMRQAWDLNPAKRPTFAELKVKLQLLNNAT 1051
            :||:|...|...|..||||..::..|.....||
Zfish   470 LYEIMTTCWKNKPEDRPTFDYIQSVLDDFYTAT 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	36/110 (33%)
		PTKc_Csk_like	793..1047	CDD:270635	115/259 (44%)
		STYKc	800..1044	CDD:214568	112/249 (45%)
lyn	NP_001004543.1	SH3_Lyn	65..120	CDD:212937	8/55 (15%)
		SH2_Src_Lyn	123..223	CDD:198227	34/105 (32%)
		PTKc_Lyn	237..508	CDD:270657	117/266 (44%)
		Pkinase_Tyr	245..495	CDD:285015	112/249 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910