DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and Shark

DIOPT Version :10

Sequence 1:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster


Alignment Length:943 Identity:225/943 - (23%)
Similarity:331/943 - (35%) Gaps:272/943 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 ARRKPILLCSSLSAAYAPPRRREFYFCDKYAPGPARSTPTTTTTSATSAKH-----------ESS 203
            ||.||.....:|.:|.|..:.|.  ..:.|.|            ...:|||           ..:
  Fly   195 ARSKPASFIRTLISAQANVQGRN--IDNGYVP------------LHEAAKHGNLEAVQELLLAEA 245

  Fly   204 PPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQTSRSLPPI-ASSEEWFD 267
            ||:.       |.:..:|....||...|...:.||.|.:             |||. .:.::|:.
  Fly   246 PPLP-------RTSSGEFPFDLAKEAGQTAVEEFLLNYK-------------LPPANTTRDQWYH 290

  Fly   268 -----EEAQARKTSHEKSQKPKPKPEEN--------HKEKEAISRKASGEGDLITVEIKQGLLRK 319
                 |||.|....|.|....| :||.:        :.|..|.|                ||:..
  Fly   291 GTLTREEAVAILKKHAKELLAK-QPEVDTSGCFLVRYSESPAAS----------------GLVLT 338

  Fly   320 QTATTTTGQAMNSHATATQNGQTTVVGHHR------GFSQPSVTVAAAAATGSTAGDPWFLQTTG 378
            ............|.|...|||.....|..:      |...|||....|.....:.|.|..|:   
  Fly   339 LLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLK--- 400

  Fly   379 HQMPPTAPLRHNKRPAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHH 443
            :.:||        :|.|:      ..|..|.|.|        ..:...:.|...|..:.||.||.
  Fly   401 YPVPP--------QPKPE------VPSFATIPRS--------NMKPKAASPATPPTPVSPHSHHQ 443

  Fly   444 RENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSI 508
                 ||                           |.|         ..|..:::|::...:..:.
  Fly   444 -----HP---------------------------HVP---------ALTITKKKQKENSSSMFNT 467

  Fly   509 LSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGM 573
            |...:|...:                                             ..:|:.:...
  Fly   468 LRLTSPKKAL---------------------------------------------FDMNSLRKNK 487

  Fly   574 HGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTA 638
            ...:|:  ....::|||..|:.       |..||:.|..       .|...||...:|:.:|||.
  Fly   488 SKGKRS--DSESSVSGSLAGTE-------QELQAAAPML-------KSLSFSTEFSTFNADGVTG 536

  Fly   639 GSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLL----Q 699
            .....|...::...........|.|.|       .:.|.::........:|.|:.|...:    |
  Fly   537 SGAAAAGEVYNVPRNNTPIEIDLPPIA-------QKTEAEVEYFTKSDVAIERERAGQWIGNGYQ 594

  Fly   700 PREDGLFLVRESTNFPGDYTL-CVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADAD 763
            |..|.|.|:.:....|....| .:...:..|.....||..|.:        ......:..|.:| 
  Fly   595 PTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCS--------GTPSTPSATEVEA- 650

  Fly   764 GLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLG-ILRNE----- 822
                         .|..|.|.           || :|.|...||.||||.|..| :||..     
  Fly   651 -------------AKLRFFIE-----------PE-KLVLDREIGHGEFGSVHSGWLLRKSGAGEE 690

  Fly   823 ---KVAVKMLKDEGA-VQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLR 883
               :||:|||.||.: .|:||.|||||..|||..:|:.||:. ..:.|.:|.|....||::.|:.
  Fly   691 SRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIA-KGEMLMMVQELAPLGSMLQYIL 754

  Fly   884 SRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLARE------ 942
            ..|.:.....:..::|...|.||.|||::..|||||||||:|::....||:||||::|.      
  Fly   755 DHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGST 819

  Fly   943 ECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGY 1007
            |......|:.||:|.|||:...|.||:.||:||||:.:||::|.|..||..|...|.:|.|:.|.
  Fly   820 EYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGE 884

  Fly  1008 KMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            ::..|..||..||.:|:..|...|..||||..|
  Fly   885 RLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYL 917

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 16/101 (16%)
PTKc_Csk_like 793..1047 CDD:270635 107/264 (41%)
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430 36/156 (23%)
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786 7/21 (33%)
ANK repeat 220..245 CDD:293786 5/36 (14%)
SH2_Cterm_shark_like 287..395 CDD:198211 26/124 (21%)
PTKc_Syk_like 666..926 CDD:270650 103/253 (41%)
Blue background indicates that the domain is not in the aligned region.

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