DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and lck

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001001596.1	Gene:	lck / 414333	ZFINID:	ZDB-GENE-040617-1	Length:	503	Species:	Danio rerio

Alignment Length:	397	Identity:	158/397 - (39%)
Similarity:	233/397 - (58%)	Gaps:	36/397 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   678 KLNAM---PWFHGSITRDEA-EHLLQP-REDGLFLVRESTNFPGDYTLCV----CFQSK-VEHYR 732
            |||:|   |||:.:::|::| ..||.| ...|.||:|||...||.:::.|    ..|.. ::|||
Zfish   111 KLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPMQGDIIKHYR 175

  Fly   733 VK-------YLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVD 790
            ::       |:.||::      |.:|.:||.||..:||||||:|:|.......|      |.:..
Zfish   176 IRNMDAGGFYITNKIS------FNSLSELVKHYSREADGLCTRLVKPCQTRAPQ------KPWWQ 228

  Fly   791 KGWVIPEAELQLRESIGKGEFGDVMLGILRNEK-VAVKMLK-DEGAVQKFLAEASVMTTLEHDNL 853
            ..|.:|...|:|...:|:|:||:|.:|:..|.: ||:|.|| ...::..|||||::|.:|:|..|
Zfish   229 DEWEVPRESLKLERRLGQGQFGEVWMGLYNNNRQVAIKSLKPGTMSISAFLAEANLMKSLQHPRL 293

  Fly   854 VKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRD 918
            |:...:| |.:.:|::||||..|||||:|::.....|.....|..|...|.||.|:|.|..:|||
Zfish   294 VRLFAVV-TQEPIYIITEYMENGSLVDFLKTPEGSDIPINTLIDMAAQVAEGMAYVEQKNYIHRD 357

  Fly   919 LAARNVLISEDCVAKVSDFGLAR----EECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGIL 979
            |.|.|:|:|.:...|::||||||    .|....:..|.|||||||||:..|.||.|||:||||:|
Zfish   358 LRAANILVSHELTCKIADFGLARLIKNNEYTAREGAKFPIKWTAPEAINYGTFSIKSDVWSFGVL 422

  Fly   980 LWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKL 1044
            |.||.::||:|||.:...:|:.::|.||:|..|:.||..:|.:|:..|..||..||||..|:..|
Zfish   423 LTEIVTYGRIPYPGMTNPEVIANLERGYRMPCPDNCPEALYNVMKHCWTENPDNRPTFEFLRSVL 487

  Fly  1045 QLLNNAT 1051
            :....||
Zfish   488 EDFFTAT 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	40/113 (35%)
		PTKc_Csk_like	793..1047	CDD:270635	112/259 (43%)
		STYKc	800..1044	CDD:214568	109/249 (44%)
lck	NP_001001596.1	SH3_Lck	57..111	CDD:212938	158/397 (40%)
		SH2_Src_Lck	116..216	CDD:198225	37/105 (35%)
		PTKc_Lck_Blk	230..493	CDD:270652	112/263 (43%)
		Pkinase_Tyr	238..487	CDD:285015	109/249 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920