DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and FER

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster

Alignment Length:	1140	Identity:	268/1140 - (23%)
Similarity:	443/1140 - (38%)	Gaps:	298/1140 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RVLKPASASASPSNSNNESDNSQTSSGSQTASSASKRSNRSVGRSHRGSIAQDTRRRYYFGSKDI 103
            ::::..:..:..:|.:..|:.|.||:|.|:...:..|.::.:....    .|:.:::...   |:
  Fly   331 KMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALR----CQEKQKQKLV---DM 388

  Fly   104 YWCKQSREAAAAATLSG--SGLTRSASSV----THKEASTHATHTGGQVISR--ARRKPILLCSS 160
            ..|..: |.......||  ..||...:.:    .:::..:::|.:.|..|..  .||..:|...
  Fly   389 IKCALN-EVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLL- 451

  Fly   161 LSAAYAPPRRREFYFCDKYAPGPA------------RSTPTTTTTSATSAKHESSPPIDAR---L 210
                    |.|..:|..|..|.||            :..|.:.:..:.|...:.:.|..||   :
  Fly   452 --------RGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPI 508

  Fly   211 LNFLRCAHRKFQASKAK----------------TELQQTKDRF--LGNSRE-----RTSKNGQQT 252
            .|     ||..||:...                |.|::|:...  ||...|     ..:...|.|
  Fly   509 TN-----HRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLT 568

  Fly   253 SRSLPPIASSEEWFDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRKASGEGDLITVEIKQGLL 317
            :..|....::..:.|.|...:|   :.|..|:.|.|:...:||.           |.:||.|
  Fly   569 AAVLTNTNNNHIYADLELDKKK---DTSPSPECKGEQIQPKKEQ-----------IRIEINQ--- 616

  Fly   318 RKQTATTTTGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAA-------TGSTAGDPWFLQ 375
                  |....::::|..........:....:...|||..|.|..:       |...|.||  ..
  Fly   617 ------TAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDP--DS 673

  Fly   376 TTGHQMPPTAPLRHNKRPAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQS------QPHIV-- 432
            .|......::..|.:|..:......|....      .::..:..:.::.|:|      :.||:
  Fly   674 QTKRSSSSSSECRSSKDTSHSKKRSLSFSQ------KSISNIFSNLKEFSKSPLVRMGKNHILNE 732

  Fly   433 ---PPSIPPHHHHHRENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSP-------SQTQ 487
               .....|..|||...:..|..:.::     ||:..|::...||.||||....       :.|.
  Fly   733 EQDAKRTQPSQHHHSSGSDCPTNSSSS-----SSNNNNNNKNTSSNSNHSASQSTIITSTITTTI 792

  Fly   488 QQQQTTNQQQQQQQ--------QQASHSILSTFA------------------------PAPTV-- 518
            ....||...::..:        |:.|.:|.:||.                        |:.:|
  Fly   793 TTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFD 857

  Fly   519 -----AAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAER 578
                 ...|||||            .|.:|       ..||||.|                  ::
  Fly   858 FAKEFEVEQPAGS------------AADEQ-------FCNCPPAG------------------QK 885

  Fly   579 ALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVN 643
            .:.| |:.:||.:          ..|.::|          ||....::..   ||:        |
  Fly   886 PVKP-SVQISGHK----------DHPFESS----------SGELDENSDR---DID--------N 918

  Fly   644 ASSAWSSGSTTAM---NH--------ASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHL 697
            ......|.|...:   :|        ||:|.:...|          |....||||.:.|:|...|
  Fly   919 DEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRP----------LYEEEWFHGVLPREEVVRL 973

  Fly   698 LQPREDGLFLVRES-TNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEY------FENLGQLV 755
            |  ..||.|||||: .|......|.||:... :|:.|:      |..:..:      |.::.:|:
  Fly   974 L--NNDGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQ------TTGEGNFRFEGPPFASIQELI 1029

  Fly   756 AH-YEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGIL 819
            .| |.::           ||...|.. .|..:....:.|.:...::.|.|.||:|.||||....|
  Fly  1030 MHQYHSE-----------LPVTVKSG-AILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL 1082

  Fly   820 RNEK--VAVK----MLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSL 878
            ::.|  ||||    .|.|| ..:|||.|..::...:|.|:||.||:....:.:.:|.|.:..|||
  Fly  1083 KSTKLDVAVKTCRMTLPDE-QKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSL 1146

  Fly   879 VDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-E 942
            :.||| :....:|.:.|:....|.|:||.|||:|..:||||||||.|:..:...|:||||::| |
  Fly  1147 LTYLR-KNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREE 1210

  Fly   943 ECYNLDVG--KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEV 1005
            |.|.:..|  ::|:||||||||..|::::..|:||:|||:|||:|.|..||..:..:...:.::.
  Fly  1211 EEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDT 1275

  Fly  1006 GYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            ||:|..|:..|.|:|.:|.|.|..:...||.|.|:
  Fly  1276 GYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	28/104 (27%)
		PTKc_Csk_like	793..1047	CDD:270635	103/257 (40%)
		STYKc	800..1044	CDD:214568	102/250 (41%)
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	29/115 (25%)
		TyrKc	1063..1311	CDD:197581	102/250 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/246 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468353
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950