DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and Ack

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_647859.1	Gene:	Ack / 38489	FlyBaseID:	FBgn0028484	Length:	1073	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	128/426 - (30%)
Similarity:	196/426 - (46%)	Gaps:	84/426 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 STTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNF-- 714
            ||:|::....|.||                  |....:...:.|..|....|.|.:.| ..:|
  Fly     3 STSAVDGGLGSETA------------------WLEDLLREVQLEQFLDRIRDDLQVTR-LAHFDY 48

  Fly   715 --PGDYTLC-----------VCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLC 766
              |.|...|           ...:.|..|...|.:.:||....::.........|...:..:|
  Fly    49 VLPDDLERCGLGKPAIRRLMEAVRKKKAHQWRKNILSKLIGGGKQPSSKKQSSAARESSQGNG-- 111

  Fly   767 TQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLG---------ILRNE 822
            ||| .||                     |.|.::.:...:|.|.||.|..|         ::
  Fly   112 TQL-TCL---------------------IHEKDITMGLKLGDGSFGVVRRGEWSASPAGKVI--- 151

  Fly   823 KVAVKMLKDE-----GAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYL 882
            .||||:||.:     |.:..|..|...|..|:|.|||:..|:|. |:.:.::||...:|||:|.|
  Fly   152 PVAVKVLKSDNLTQPGIIDDFFREVQAMHALDHANLVRLYGVVL-SQPMMMITELAERGSLLDTL 215

  Fly   883 RSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----E 942
            |.:.| |.:......::....:||.|||.|:.:|||||.||||::.....|:.||||.|     :
  Fly   216 RKQCR-HTSLTIIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAAGNKIKIGDFGLMRALPQED 279

  Fly   943 ECYNL-DVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVE-V 1005
            :||.: :..|:|..|.|||:|:..:||:.||.|.||:.|||::|||..|:..:..:.:::.:: .
  Fly   280 DCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFGEDPWVGLNGSQILRKIDRE 344

  Fly  1006 GYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELK 1041
            |.::..|:.|||::|.||.|.||..||:|||||.||
  Fly   345 GERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALK 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	22/111 (20%)
		PTKc_Csk_like	793..1047	CDD:270635	100/270 (37%)
		STYKc	800..1044	CDD:214568	98/263 (37%)
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	12/79 (15%)
		PTKc_Ack_like	128..385	CDD:270636	98/258 (38%)
		UBA_TNK1	1031..1070	CDD:270513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468354
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940