Protein Alignment Csk and JAK2

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_004963.1
• Gene: JAK2 / 3717
• HGNCID: 6192
• Length: 1132
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 99/290 - (34%)
• Similarity: 165/290 - (56%)
• Gaps: 43/290 - (14%)

  Fly   797 EAELQLRESIGKGEFGDV------MLGILRNEKVAVKMLK--DEGAVQKFLAEASVMTTLEHDNL 853
            |..|:..:.:|||.||.|      .|.....|.||||.|:  .|..::.|..|..::.:|:|||:
Human   846 ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI 910

  Fly   854 VKFIGLVFTS--KHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQI-IFAYDT--ASGMEYLEAKK 913
            ||:.|:.:::  ::|.|:.||:..|||.|||    ::|..:.|.| :..|.:  ..|||||..|:
Human   911 VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYL----QKHKERIDHIKLLQYTSQICKGMEYLGTKR 971

  Fly   914 VVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYNL-DVGKLPIKWTAPEALKNGRFSNKSD 972
            .:|||||.||:|:..:...|:.||||.:     :|.|.: :.|:.||.|.|||:|...:||..||
Human   972 YIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASD 1036

  Fly   973 MWSFGILLWEIYSFGRVPYPRIPLAD-------------VVKH-VEV---GYKMEAPEGCPPEIY 1020
            :||||::|:|::::  :...:.|.|:             :|.| :|:   ..::..|:|||.|||
Human  1037 VWSFGVVLYELFTY--IEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIY 1099

  Fly  1021 EMMRQAWDLNPAKRPTFAELKVKL-QLLNN 1049
            .:|.:.|:.|..:||:|.:|.::: |:.:|
Human  1100 MIMTECWNNNVNQRPSFRDLALRVDQIRDN 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190
		PTKc_Csk_like	793..1047	CDD:270635	98/286 (34%)
JAK2	NP_004963.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239
		FERM_F1	39..134	CDD:465733
		FERM_F2	143..261	CDD:436450
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663
		PTKc_Jak2_rpt2	844..1127	CDD:271107	98/286 (34%)