DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and JAK1

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001307852.1	Gene:	JAK1 / 3716	HGNCID:	6190	Length:	1154	Species:	Homo sapiens

Alignment Length:	465	Identity:	117/465 - (25%)
Similarity:	203/465 - (43%)	Gaps:	96/465 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   634 NGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLL 698
            |.:.|..|:::    ..|....::...:..|.|:    |..|   :..:||.......|
Human   719 NLLLAREGIDS----ECGPFIKLSDPGIPITVLS----RQEC---IERIPWIAPECVED------ 766

  Fly   699 QPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFEN-----------LG 752
               ...|.:..:..:| |.....:|:..::.      |::|..|:.|.::|:           |.
Human   767 ---SKNLSVAADKWSF-GTTLWEICYNGEIP------LKDKTLIEKERFYESRCRPVTPSCKELA 821

  Fly   753 QLVA---HYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAE--------LQLRESI 806
            .|:.   :|:.:.......:::.:.||.:|     :.|.|.:.....|.:        |:....:
Human   822 DLMTRCMNYDPNQRPFFRAIMRDINKLEEQ-----NPDIVSEKKPATEVDPTHFEKRFLKRIRDL 881

  Fly   807 GKGEFGDVML------GILRNEKVAVKMLKDEGA---VQKFLAEASVMTTLEHDNLVKFIGLVFT 862
            |:|.||.|.|      |....|:||||.||.|..   :.....|..::..|.|:|:||:.|:...
Human   882 GEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTE 946

  Fly   863 --SKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVL 925
              ...:.|:.|::..|||.:|| .:.:..|..|.|:.:|.....||:||.:::.|||||||||||
Human   947 DGGNGIKLIMEFLPSGSLKEYL-PKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVL 1010

  Fly   926 ISEDCVAKVSDFGLAR-----EECYNL-DVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIY 984
            :..:...|:.||||.:     :|.|.: |....|:.|.|||.|...:|...||:||||:.|.|:.
Human  1011 VESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELL 1075

  Fly   985 SF-------------------GRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLN 1030
            ::                   |::...|:     |..::.|.::..|..||.|:|::||:.|:..
Human  1076 TYCDSDSSPMALFLKMIGPTHGQMTVTRL-----VNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQ 1135

  Fly  1031 PAKRPTFAEL 1040
            |:.|.:|..|
Human  1136 PSNRTSFQNL 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	16/110 (15%)
		PTKc_Csk_like	793..1047	CDD:270635	89/292 (30%)
		STYKc	800..1044	CDD:214568	88/277 (32%)
JAK1	NP_001307852.1	B41	37..286	CDD:214604
		FERM_C_JAK1	282..426	CDD:275412
		SH2	426..527	CDD:301589
		PTK_Jak1_rpt1	583..846	CDD:270662	23/153 (15%)
		Pkinase_Tyr	583..845	CDD:285015	23/152 (15%)
		PTKc_Jak1_rpt2	870..1153	CDD:173644	88/282 (31%)
		TyrKc	875..1149	CDD:197581	88/277 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810