DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and ITK

DIOPT Version :10

Sequence 1:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_005537.3 Gene:ITK / 3702 HGNCID:6171 Length:620 Species:Homo sapiens


Alignment Length:386 Identity:136/386 - (35%)
Similarity:210/386 - (54%) Gaps:35/386 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   679 LNAMPWFHGSITRDEAEH-LLQPREDGLFLVRESTNFPGDYTLCVCFQSKV-------EHYRVKY 735
            |....|::.||:||:||. ||...::|.|:||:|.. .|.||:.|..::.|       :||.:|.
Human   234 LETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRT-AGTYTVSVFTKAVVSENNPCIKHYHIKE 297

  Fly   736 LEN---KLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCI-NSKDFVDKG---- 792
            ..:   :..:.::..|:::..|:.:::.:..||.|:|        :...|. ..|..|..|    
Human   298 TNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRL--------RYPVCFGRQKAPVTAGLRYG 354

  Fly   793 -WVIPEAELQLRESIGKGEFGDVMLGI-LRNEKVAVKMLKDEGAV--QKFLAEASVMTTLEHDNL 853
             |||..:||...:.||.|:||.|.||. |..:|||:|.:: |||:  :.|:.||.||..|.|..|
Human   355 KWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIR-EGAMSEEDFIEEAEVMMKLSHPKL 418

  Fly   854 VKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRD 918
            |:..|:......:.||.|:|..|.|.||||:: |.....:..:....|...||.|||...|:|||
Human   419 VQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ-RGLFAAETLLGMCLDVCEGMAYLEEACVIHRD 482

  Fly   919 LAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGIL 979
            |||||.|:.|:.|.||||||:.|   ::.|....| |.|:||.:||.....|:|:|||:||||:|
Human   483 LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVL 547

  Fly   980 LWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            :||::|.|::||.....::||:.:..|:::..|......:|::|...|...|..||.|:.|
Human   548 MWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRL 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 28/107 (26%)
PTKc_Csk_like 793..1047 CDD:270635 103/255 (40%)
ITKNP_005537.3 PH_Btk 7..148 CDD:269944
SH3_ITK 174..229 CDD:212841
SH2_Tec_Itk 232..340 CDD:198259 29/114 (25%)
PTKc_Itk 358..613 CDD:133243 101/253 (40%)
Blue background indicates that the domain is not in the aligned region.

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