DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and Btk29A

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	938	Identity:	251/938 - (26%)
Similarity:	356/938 - (37%)	Gaps:	258/938 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 SAKHESSPPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQTSRSLPPIAS 261
            |.|..||          ||.:.:.||   ||.:|.  .:|.....:..:.....|..:...|:..
  Fly    14 SIKSSSS----------LRSSSKSFQ---AKMDLM--SERLYDVVKSGSMVKRAQNKKRFTPVNY 63

  Fly   262 SEEWFDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRK---------ASGEG------DLITVE 311
            ...||  |...|..|:...:.     .|..:|:..|..|         .||||      |....
  Fly    64 KHRWF--ELTKRTFSYFDVEN-----VERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPF- 120

  Fly   312 IKQGLLRKQTATTTTGQAMNSHATATQNGQTT---VVGHHRGFSQPSVTVAAAAATGSTAGDPW- 372
                    |........:.|||.....||..:   :.|...|.:.|..|:...|.:.....: |
  Fly   121 --------QVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSE-WI 176

  Fly   373 --FLQTTGHQMPPTAPLRHNKRPAPQPNAVLG------AGSSGTAPGSAVGAVLLHQQQLSQSQP 429
              ..|.......|.:...|       |....|      .|.|.|..|....|
  Fly   177 RAIRQVCEDSNTPKSYRYH-------PGLWSGKKWSCCKGLSRTTFGCRAAA------------- 221

  Fly   430 HIVPPSIPPHHHHHRENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTN 494
                        |.||.|.:|...        ||.|.||...||..|:              |||
  Fly   222 ------------HWREANNNPSNG--------SSPAQNSTRSISPNSS--------------TTN 252

  Fly   495 QQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGA 559
            .|                      .::|...|.|:.|...                      ||.
  Fly   253 SQ----------------------FSLQHNSSGSLGGGVG----------------------GGL 273

  Fly   560 GLMSSSLNAAQMGMHG--------AERALPPKSLALSGSQ-----HGSNMLLHTAPQPPQASQPA 611
            |      ....:|:.|        ...:|.|:|...:..|     :|:..||       .|:.|.
  Fly   274 G------GGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLL-------DANMPG 325

  Fly   612 AV--VGVSGSGSAGMS------TSLHSFD-INGVTAGSGVNA--------SSAW-----SSGSTT 654
            .:  .|...|.:...|      .:|:.|. |.|.......||        ...|     :.|:..
  Fly   326 GIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVG 390

  Fly   655 AMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLL-QPREDGLFLVRESTNFPGDY 718
            .:....:.|.||.   |..|.|       |:.|.::|..||.|| |..::|.|:||:|:. .|.|
  Fly   391 YIPSNYVKPKALL---GLERYE-------WYVGDMSRQRAESLLKQGDKEGCFVVRKSST-KGLY 444

  Fly   719 TLCV---CFQSKVEHYRVK-------YLENKLTIDDEEYFENLGQLVAHYEADADGLCTQL--IK 771
            ||.:   ..||.|:||.:|       ||..|      ...|.:..|:.::..::.||..:|  ..
  Fly   445 TLSLHTKVPQSHVKHYHIKQNARCEYYLSEK------HCCETIPDLINYHRHNSGGLACRLKSSP 503

  Fly   772 C----LPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKD 831
            |    .|..|...         || |.|...||.|.|.:|.|:||.|..|..|.. ..||||:|
  Fly   504 CDRPVPPTAGLSH---------DK-WEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMK- 557

  Fly   832 EGAVQK--FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKD 894
            ||.:.:  |:.||.|||.|:|.|||:..|:....:.:|:|||||..|||::|||...:..|....
  Fly   558 EGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMG 622

  Fly   895 QII-FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPI 954
            .:: .....:.||.|||....:||||||||.|:..:.|.||:||||||   ::.|....| |.||
  Fly   623 LLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPI 687

  Fly   955 KWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEI 1019
            ||..||.|...|||:|||:|::|:|:|||::.|::||.|:...:||:.|:.|..:|.|:.|..||
  Fly   688 KWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEI 752

  Fly  1020 YEMMRQAWDLNPAKRPTFAELKVKLQLL 1047
            |::|:..|...|.:||.|..|..:|.|:
  Fly   753 YDVMKLCWSHGPEERPAFRVLMDQLALV 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	33/113 (29%)
		PTKc_Csk_like	793..1047	CDD:270635	112/261 (43%)
		STYKc	800..1044	CDD:214568	108/251 (43%)
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	38/226 (17%)
		SH3_Tec_like	346..399	CDD:212702	8/52 (15%)
		SH2_Tec_family	403..505	CDD:198188	34/118 (29%)
		PTKc_Tec_like	521..778	CDD:173637	110/257 (43%)
		Pkinase_Tyr	526..777	CDD:285015	108/251 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468342
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	1	0.900	-	-		E2759_KOG0197
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850