Protein Alignment Csk and sev

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Alignment Length: 1179
• Identity: 242/1179 - (20%)
• Similarity: 423/1179 - (35%)
• Gaps: 331/1179 - (28%)

  Fly   111 EAAAAATLSGSGLTRSASSVTHKEASTHATHTGGQV-------------------ISRARRKPIL 156
            ||..|||.:.:|            |::||.|...:|                   .:|.||:.:.
  Fly  1375 EARVAATGAAAG------------AASHALHVAPEVQAVPRVLYANAEFIGELDLDTRNRRRLVH 1427

  Fly   157 LCSSLSAAYAPPRRREFYFCDK------YAPG--PARSTPTTTTTSATS----------AKHESS 203
            ..|.:.........:...:.::      :.||  ||:.........|.:          |:.:::
  Fly  1428 TASPVEHLVGIEGEQRLLWVNEHVELLTHVPGSAPAKLARMRAEVLALAVDWIQRIVYWAELDAT 1492

  Fly   204 PPIDARLLNFLRC--------AHRKFQASKAK-----TELQQTKDRFLGNSRERTSKNGQQTSRS 255
            .|..|.:.....|        ..|.:...:.:     ..|.|.:........:.:.:||....|:
  Fly  1493 APQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQGSPRNGSLRGRN 1557

  Fly   256 LPPIASSEEWFDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRKASGEGDLITVEIKQGLLRKQ 320
            |.. .|..||...:...|  .|..|.:|         ..|.:: ....:|.|...::.:.|
  Fly  1558 LTD-GSELEWATVQPLIR--LHAGSLEP---------GSETLN-LVDNQGKLCVYDVARQL---- 1605

  Fly   321 TATTTTGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGSTAGDPWFLQTTG---HQMP 382
                .|..|:.:.....  |:.::.|.   .:|.|..:.|.        ..|.::..|   .|:.
  Fly  1606 ----CTASALRAQLNLL--GEDSIAGQ---LAQDSGYLYAV--------KNWSIRAYGRRRQQLE 1653

  Fly   383 PTAPLR---------HNKRPAPQPNAVLGAGSSGT---APGSAVGAVLLHQQQLSQSQPHIVP-P 434
            .|..|.         ||.:..|..|.:|...|.|:   |........|||...::.|:...:| |
  Fly  1654 YTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATDCEEQRCLLHLPMITASEDCPLPIP 1718

  Fly   435 SI----------PPHHHHHRENNVHPI---QAGAAAALHLS----------SHALNSH------- 469
            .:          .|....| ::.:.|:   ..||..:|:|:          |..|:|.
  Fly  1719 GVRYQLNLTLAKEPGSEEH-DHGMEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLAL 1782

  Fly   470 --------NLISSASNHSPK--------SPSQTQ-------------------QQQQTTNQQQQQ 499
                    .|:::::..||.        ||.:.:                   .||:...:..|.
  Fly  1783 PTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQLRSESVYYTLHWQQELDGENVQD 1847

  Fly   500 QQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCP--------- 555
            :::..:|......|....:..::|....|:...|.|....:...::.|::..|..|
  Fly  1848 RREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGP 1912

  Fly   556 ------------PGGAGLMSSSLNAAQM-----GMHG--AERALPPKS----------LALSGS- 590
                        |.|:..:....:|.|:     |.|.  ....|.|::          .|..|:
  Fly  1913 YSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAP 1977

  Fly   591 -QHGSNMLLHTAPQPPQASQPA---------AVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNAS 645
             .||:..:..|....|  |||.         .|..|:.:.:.|....:..:::..:.|.|.:...
  Fly  1978 LYHGTAEVYETLGDAP--SQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQARSDIRRR 2040

  Fly   646 SAW----SSGSTTAMNHASLSPTALAPQ------QGRSRCEVK-----------LNAMPWFHG-S 688
            ...    |.||...:..|. .|..:..|      .....|.||           :.|....|| .
  Fly  2041 RRRRRRNSGGSLEQLPWAE-EPVVVEDQWLDFCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWG 2104

  Fly   689 ITRDEAEHLLQP------REDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEY 747
            ...:|:|.:.:|      |...:..:...........|.:....||:..|:: .:..|.......
  Fly  2105 PYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVRKVQKRRLR-AKKLLQQSRPSI 2168

  Fly   748 FENLGQLVAHYE-------------ADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAE 799
            :.||..|....:             :|||      |..||::               .|    ::
  Fly  2169 WSNLSTLQTQQQLMAVRNRAFSTTLSDAD------IALLPQI---------------NW----SQ 2208

  Fly   800 LQLRESIGKGEFGDVMLGILRNE------KVAVKMLKDEGAVQ--KFLAEASVMTTLEHDNLVKF 856
            |:|...:|.|.||:|..|.|:.|      :||:|.|: :||.:  :.|.||.:|:..:|:|:|..
  Fly  2209 LKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLR-KGASEFAELLQEAQLMSNFKHENIVCL 2272

  Fly   857 IGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQ----------IIFAYDTASGMEYLEA 911
            :|:.|.::.:.|:.|:|..|.|:.|||: .|...|::.|          :....|.|:|..|||.
  Fly  2273 VGICFDTESISLIMEHMEAGDLLSYLRA-ARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLED 2336

  Fly   912 KKVVHRDLAARNVLISEDC-------VAKVSDFGLAREECYNLDV------GKLPIKWTAPEALK 963
            ...||||||.||.|::|..       ..|:.|||||| :.|..|.      |.||::|.:||:|.
  Fly  2337 MHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLAR-DIYKSDYYRKEGEGLLPVRWMSPESLV 2400

  Fly   964 NGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWD 1028
            :|.|:.:||:|:||:|.|||.:.|:.||......:|:.||:.|.:::.|..|..::|.::...|.
  Fly  2401 DGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWR 2465

  Fly  1029 LNPAKRPTF 1037
            .:|.:||:|
  Fly  2466 TDPWERPSF 2474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	21/116 (18%)
		PTKc_Csk_like	793..1047	CDD:270635	95/276 (34%)
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	13/90 (14%)
		FN3	1993..2111	CDD:238020	22/120 (18%)
		PTKc_c-ros	2213..2483	CDD:270640	92/265 (35%)