DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and Csk

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001025210.1	Gene:	Csk / 315707	RGDID:	1308800	Length:	450	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	242/445 - (54%)
Similarity:	301/445 - (67%)	Gaps:	13/445 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   606 QASQPA---AVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALA 667
            |||.|:   .:...:..|:|.........|:..:.|   |.....|.. :...:....:.|....
  Rat     5 QASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVA---VTKDPNWYK-AKNKVGREGIIPANYV 65

  Fly   668 PQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYR 732
            .::...:...||:.||||||.|||::||.||.|.|.||||||||||:||||||||..:.||||||
  Rat    66 QKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYR 130

  Fly   733 VKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKD-FVDKGWVIP 796
            :.|..:||:||:|.|||||.|||.||..|||||||:|||  ||:  .|..:.::| |...||.:.
  Rat   131 IMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIK--PKV--MEGTVAAQDEFYRSGWALN 191

  Fly   797 EAELQLRESIGKGEFGDVMLGILRNEKVAVKMLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVF 861
            ..||:|.::||||||||||||..|..|||||.:|::...|.|||||||||.|.|.|||:.:|::.
  Rat   192 MKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256

  Fly   862 TSK-HLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVL 925
            ..| .||:|||||:|||||||||||||..:.....:.|:.|....|||||....|||||||||||
  Rat   257 EEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVL 321

  Fly   926 ISEDCVAKVSDFGLAREECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVP 990
            :|||.|||||||||.:|.....|.||||:||||||||:..:||.|||:|||||||||||||||||
  Rat   322 VSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP 386

  Fly   991 YPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQ 1045
            ||||||.|||..||.||||:||:||||.:|::|:..|.|:.|.||||.:|:.:|:
  Rat   387 YPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	67/96 (70%)
		PTKc_Csk_like	793..1047	CDD:270635	158/254 (62%)
		STYKc	800..1044	CDD:214568	155/244 (64%)
Csk	NP_001025210.1	Interaction with PTPN22. /evidence=ECO:0000250\|UniProtKB:P41240	9..70		8/63 (13%)
		SH3_CSK	11..67	CDD:212703	7/55 (13%)
		SH2_csk_like	78..175	CDD:198190	67/96 (70%)
		PTKc_Csk	188..443	CDD:133213	158/255 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	315	1.000	Domainoid score	I1241
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55818
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm46279
orthoMCL	1	0.900	-	-		OOG6_107422
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2621
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.810