Protein Alignment Csk and ret

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_858048.2
• Gene: ret / 30512
• ZFINID: ZDB-GENE-980526-307
• Length: 1106
• Species: Danio rerio
• Alignment Length: 658
• Identity: 155/658 - (23%)
• Similarity: 247/658 - (37%)
• Gaps: 226/658 - (34%)

  Fly   485 QTQQQQQTTNQQQQQQQQQASHSI----------LSTFAPA-PTVAAVQPAGSQSVAGTAAAVAA 538
            :.|:.:.....|:||.:.||...:          |.|..|. |..|..:..|.........|...
Zfish   470 ECQELEYVVIAQEQQNKLQAKTQLTVSFQGEADSLKTDEPRFPACAEKRQRGDCEATRGLGAPTG 534

  Fly   539 VAQQQQQQHLQL----------LANCPPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHG 593
            ..|.:|.:...:          |..||.|...                  |:..|::::.
Zfish   535 RCQWRQGRDKGISKRYSTCSPNLGTCPDGYCD------------------AIESKNISIC----- 576

  Fly   594 SNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNH 658
                       ||.....|::|.            :..|:.|:.||.|.....
Zfish   577 -----------PQDCSSEAIIGG------------YERDLYGIKAGHGTCYCF------------ 606

  Fly   659 ASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPRED------------GLFL---- 707
                       :|:..||              |||      |.:|            |:.|
Zfish   607 -----------EGKCFCE--------------RDE------PEDDICNDMCKTVIATGIILSFIV 640

  Fly   708 -----------VRESTNFPGDYTLCVCFQSKVEHYRVKY------------LENKLTIDDEEYFE 749
                       ..::|..|...:..:.|:...:.|.:.|            :||::.||..:
Zfish   641 SVLLSSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDSMENQVAIDTFK--- 702

  Fly   750 NLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDV 814
                                   :|:              |..|..|...|.|.:::|:||||.|
Zfish   703 -----------------------IPE--------------DPKWEFPRKNLVLGKTLGEGEFGKV 730

  Fly   815 -------MLGILRNEKVAVKMLKDEGA---VQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLV 869
                   :.|......|||||||:..:   ::..|:|.:::..:.|.:::|..|.......|||:
Zfish   731 VKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLI 795

  Fly   870 TEYMSKGSLVDYLRSRGR----------------------QHITKKDQIIFAYDTASGMEYLEAK 912
            .||...|||.::||...:                      :.:|..|.|.||:..:.||:||...
Zfish   796 VEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEM 860

  Fly   913 KVVHRDLAARNVLISEDCVAKVSDFGLAR----EECY-NLDVGKLPIKWTAPEALKNGRFSNKSD 972
            |:|||||||||||::|....|:|||||:|    |:.| ....|::|:||.|.|:|.:..::.:||
Zfish   861 KLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSD 925

  Fly   973 MWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTF 1037
            :||||:|||||.:.|..|||.|....:...::.||:||.||.|..|:|.:|.:.|.....|||||
Zfish   926 VWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTF 990

  Fly  1038 AELKVKLQ 1045
            :::..:|:
Zfish   991 SDISKELE 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	17/135 (13%)
		PTKc_Csk_like	793..1047	CDD:270635	104/290 (36%)
ret	NP_858048.2	RET_CLD1	23..140	CDD:465485
		CA	186..256	CDD:214520
		RET_CLD3	251..364	CDD:465516
		RET_CLD4	388..499	CDD:465517	6/28 (21%)
		PTKc_RET	715..1004	CDD:173631	102/284 (36%)