DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and Abl2

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_038946666.1	Gene:	Abl2 / 304883	RGDID:	1590898	Length:	1188	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	194/563 - (34%)
Similarity:	282/563 - (50%)	Gaps:	67/563 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 QQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGG-----AG 560
            ||.....|..:.|..|:.....|.|..:.||.....       |..|   .|:|...|     .|
  Rat    15 QQPQPRGIRGSSAARPSGRRRDPVGRTADAGFNVFT-------QHDH---FASCVEDGFEGDKTG 69

  Fly   561 LMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMS 625
            ..|..:.....|.....:|| .:::..|..:   |:|..|...|                  .:.
  Rat    70 GSSPEVLHRPFGCDAESQAL-NEAIRWSSKE---NLLGATESDP------------------NLF 112

  Fly   626 TSLHSFDING-----VTAGS-----GVNASSAWSSGSTTAMNHASLSPT-ALAPQQGRSRCEVKL 679
            .:|:.|..:|     :|.|.     |.|.:..||  ...:.|.....|: .:.|..       .|
  Rat   113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWS--EVRSKNGQGWVPSNYITPVN-------SL 168

  Fly   680 NAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVK-YLENKLTID 743
            ....|:||.::|..||:||....:|.||||||.:.||..::.:.::.:|.|||:. ..::|:.:.
  Rat   169 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTTDSKVYVT 233

  Fly   744 DEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGK 808
            .|..|..|.:||.|:...||||.|.|....||..|.  .:.....:...|.:...::.::..:|.
  Rat   234 AESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKP--TVYGVSPIHDKWEMERTDITMKHKLGG 296

  Fly   809 GEFGDVMLGILRNEK--VAVKMLK-DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVT 870
            |::|:|.:|:.:...  ||||.|| |...|::||.||:||..::|.|||:.:|:.......|:||
  Rat   297 GQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVT 361

  Fly   871 EYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVS 935
            |||..|:|:||||...|:.:|....:..|...:|.|||||.|..:||||||||.|:.|:.|.||:
  Rat   362 EYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVA 426

  Fly   936 DFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPL 996
            ||||:|   .:.|....| |.||||||||:|....||.|||:|:||:|||||.::|..|||.|.|
  Rat   427 DFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDL 491

  Fly   997 ADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAE 1039
            :.|...:|.||:||.||||||::||:||..|..:||.||:|||
  Rat   492 SQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	36/97 (37%)
		PTKc_Csk_like	793..1047	CDD:270635	120/254 (47%)
		STYKc	800..1044	CDD:214568	119/247 (48%)
Abl2	XP_038946666.1	SH3_Abl	111..164	CDD:212784	11/54 (20%)
		SH2_ABL	169..262	CDD:198189	34/92 (37%)
		PTKc_Abl	281..543	CDD:270645	120/254 (47%)
		FABD	1069..1188	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910