Protein Alignment Csk and jak1

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_571148.1
• Gene: jak1 / 30280
• ZFINID: ZDB-GENE-980526-142
• Length: 1153
• Species: Danio rerio
• Alignment Length: 664
• Identity: 153/664 - (23%)
• Similarity: 267/664 - (40%)
• Gaps: 144/664 - (21%)

  Fly   470 NLISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASH-----------SILSTFA---------- 513
            ||:...::..|....:||..|.:.::..:::..|..|           .||...:
Zfish   549 NLLVMTTDREPVPQKKTQVSQLSFDRILKEEIVQGEHLGRGTRTNIYAGILKPKSDDEDDLGGYS 613

  Fly   514 -PAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLAN-CPPGGAGLMSSSLNAAQMGMHGA 576
             ....|..|..:|.:.::......|::.:|...:|:.||.. |......:|....  .|.|
Zfish   614 QEVKVVLKVLGSGHRDISLAFFETASMMRQISHKHIALLYGVCVRHQENIMVEEF--VQYG---- 672

  Fly   577 ERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSF--DINGVTAG 639
                 |..|.:    ......|.||.:...|.|.|:.:.....     ...:|.:  ..|.:.|.
Zfish   673 -----PLDLFM----RRQTTPLSTAWKFQVAKQLASALSYLED-----KKMVHGYVCSKNILVAR 723

  Fly   640 SGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDG 704
            .|::.    ..|....::...:..|.|:    |..|   ::.:||......:|.|         .
Zfish   724 DGLDG----EGGPFIKLSDPGIPITVLS----REEC---VDRIPWIAPECVKDTA---------N 768

  Fly   705 LFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQL 769
            |.:..:..:| |.....:|:..::.      |::|...:.|.::....||..   .|.|.|...:
Zfish   769 LSIAADKWSF-GTTLWEICYNGEIP------LKDKKLTEKERFYAAQCQLAT---PDCDELAKLM 823

  Fly   770 IKCLPKLGKQEFCINS--KD--FVDKG----WVIPEAEL-----------QLRESIGKGEFGDVM 815
            ..|:....:|.....:  :|  .|:|.    ..:|..|:           ::|: :|:|.||.|.
Zfish   824 THCMTYDPRQRLFFRAIVRDIVMVEKQNPSIQPVPMLEVDPTVFEKRFLKKIRD-LGEGHFGKVE 887

  Fly   816 L------GILRNEKVAVKMLKDEGAVQK---FLAEASVMTTLEHDNLVKFIGLVFT--SKHLYLV 869
            |      |....|.||||.||.|...::   ...|..::..|.|:|:||:.|:...  .:.:.|:
Zfish   888 LCRYDPRGDRTGELVAVKSLKPENREEQSNNLWREIHILRELYHENIVKYKGICNEEGGRSIKLI 952

  Fly   870 TEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKV 934
            .|::..|||.:|| .|.:.||..|..:.::.....||:||.::..:||||||||||:..:...|:
Zfish   953 MEFLPAGSLKEYL-PRNKAHINLKTLLNYSVQICQGMDYLGSRNYIHRDLAARNVLVENEGTVKI 1016

  Fly   935 SDFGLAR----EECY-----NLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSF---- 986
            .||||.:    .|.|     :||   .|:.|.|||.|.:.:|...||:||||:.::|:.::
Zfish  1017 GDFGLTKSIKDNEGYYTVKDDLD---SPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDAS 1078

  Fly   987 ---------------GRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPT 1036
                           |::...|:     ||.:|.|.::..|:.|..::|.:||:.|:..|.||..
Zfish  1079 CSPMSVFLKLIGPTHGQMTVTRL-----VKVLEEGKRLPRPDDCSEQLYNLMRRCWEATPEKRIN 1138

  Fly  1037 FAELKVKL-QLLNN 1049
            |..|.... |:|:|
Zfish  1139 FKSLIANFQQMLDN 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	17/96 (18%)
		PTKc_Csk_like	793..1047	CDD:270635	91/304 (30%)
jak1	NP_571148.1	FERM_F1	34..127	CDD:465733
		FERM_F2	145..275	CDD:436450
		FERM_C_JAK1	280..422	CDD:275412
		SH2_Jak1	422..523	CDD:198241
		PTK_Jak1_rpt1	580..845	CDD:270662	52/314 (17%)
		Protein Kinases, catalytic domain	867..1150	CDD:473864	89/292 (30%)