Protein Alignment Csk and Fer

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001382687.1
• Gene: Fer / 301737
• RGDID: 1306273
• Length: 823
• Species: Rattus norvegicus
• Alignment Length: 893
• Identity: 234/893 - (26%)
• Similarity: 364/893 - (40%)
• Gaps: 208/893 - (23%)

  Fly   196 TSAKHESSPPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQTSRSLPPIA 260
            |.|:..:|.|:           ||.....|.|   ||.|..::|..::..::..:.|...|..:.
  Rat    87 THAEDLNSGPL-----------HRLTMMIKDK---QQVKKSYVGIHQQIEAEMIKVTKTELEKLK 137

  Fly   261 SSEEWFDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRKASGEGDLITVEIKQGLLRKQTATTT 325
            ||.....:|..:.|   ||.::...|.:|..|.||...:          ..:|..:|..|.....
  Rat   138 SSYRQLIKEMNSAK---EKYKEALAKGKETEKAKERCDK----------ATMKLHMLHNQYVLAL 189

  Fly   326 TGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGSTAGDPWFLQTTGHQMPPTAPLRHN 390
            .|..::.    :|...||:                          |..|.:.            .
  Rat   190 KGAQLHQ----SQYYDTTL--------------------------PLLLDSV------------Q 212

  Fly   391 KRPAPQPNAVLGAGSSGTAPGSAV--GAVLLHQQ-QLSQSQPHIVPPSIPPHHHHHRENNVHPIQ 452
            |.......|:.|.....:...|.|  ..|.:|:: |:|..|       |.|...::...:||...
  Rat   213 KMQEEMIKALKGIFDEYSEITSLVTEEIVNVHKEIQMSVDQ-------IDPSTEYNDFIDVHRTT 270

  Fly   453 AGAAAALHLSSHAL-NSHNLISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSILSTFAPAP 516
            |.....:...:..| .:.||.::....:..:....|...:|..::..|.||...|...:......
  Rat   271 AAKEQEIEFDTSLLEENENLQANEIMWNNLTADSLQVMLKTLAEELTQTQQMLLHKEAAVLELEK 335

  Fly   517 TVAAVQPAGSQSVAGTAAAVAAVAQQQQ----QQHLQLL----ANCPPGGAGLMSSSLNAAQMGM 573
            .:    ...|::.|..:..|..:.|:|.    :|.:|.|    |.|             |||
  Rat   336 RI----EESSETCAKKSDIVLLLGQKQALEELKQSVQQLRCTEAKC-------------AAQ--- 380

  Fly   574 HGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTS----LHSFD-- 632
                                 ..||....|.....:|..||.......:..|..    |..|:
  Rat   381 ---------------------KELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESI 424

  Fly   633 ---INGV------TAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGS 688
               |.|:      ..||....|...|.|......|                        .|:||:
  Rat   425 RHSIAGIIKSPKSVLGSSTQLSDVISVGEKPLAEH------------------------DWYHGA 465

  Fly   689 ITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQ 753
            |.|.||:.||  ::.|.||||||...||:|.|.|....:..|:.:::::|....:... |.|:.|
  Rat   466 IPRIEAQELL--KQQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQFVDNLYRFEGTG-FSNIPQ 527

  Fly   754 LVAHYEADADGLCTQ-----LIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGD 813
            |:.|: .:...:.|:     |:..:||              ||.||:...::.|.|.:|||.||:
  Rat   528 LIDHH-FNTKQVITKKSGVVLLNPIPK--------------DKKWVLNHEDVSLGELLGKGNFGE 577

  Fly   814 VMLGILRNE-KVAVKMLKDEGAVQ---KFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMS 874
            |..|.|::: .||||..|::...:   |||.||.::...:|.|:||.||:....:.:|::.|.:.
  Rat   578 VYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVP 642

  Fly   875 KGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGL 939
            .|..:.:||.| :..:..|..:.|:.|.|:||.|||.|..:||||||||.|:.|:...|:||||:
  Rat   643 GGDFLSFLRKR-KDELKLKQLVRFSLDVAAGMLYLEGKNCIHRDLAARNCLVGENNTLKISDFGM 706

  Fly   940 AREECYNLDVG--------KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPL 996
            :|:|    |.|        ::||||||||||..||:|::||:|||||||||.:|.|..|||.:..
  Rat   707 SRQE----DGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTN 767

  Fly   997 ADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKL 1044
            ....:.||.||:|.||:.||.||:.:|.:.||..|..||.|::|..:|
  Rat   768 QQAREQVERGYRMSAPQNCPEEIFTIMMKCWDYKPENRPKFSDLHKEL 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	32/101 (32%)
		PTKc_Csk_like	793..1047	CDD:270635	112/264 (42%)
Fer	NP_001382687.1	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		52/288 (18%)
		F-BAR_Fer	5..238	CDD:153370	39/219 (18%)
		SH2_Fps_family	454..539	CDD:198224	29/112 (26%)
		Protein Kinases, catalytic domain	567..817	CDD:473864	109/254 (43%)